PMID: 8602666Feb 1, 1996Paper

Dose responses for neostigmine and edrophonium as antagonists of mivacurium in adults and children

Anesthesiology
J C BevanD R Bevan

Abstract

Reversal of neuromuscular blockade induced with pancuronium, d-tubocurarine, or doxacurium is achieved using smaller doses of neostigmine in adults than in children. Also, pancuronium- and doxacurium-induced blockade is reversed with smaller doses of edrophonium in children than in adults. The purpose of this study was to compare the spontaneous and neostigmine- and edrophonium-assisted recovery of mivacurium-induced neuromuscular block in adults and children. Fifty-four adults, aged 40.1 +/- 10.9 yr, and 54 children, aged 4.9 +/- 0.7 yr, physical status ASA 1-2, were studied during propofol/fentanyl/nitrous oxide anesthesia. A Datex relaxograph was used to monitor the electromyographic response of the adductor pollicis to train-of-four stimulation of the ulnar nerve every 10 s. After induction of anesthesia, 0.2 mg x kg(-1) intravenous mivacurium was administered followed by an infusion to maintain 90-95% T1 block. At the end of surgery, one of four doses of neostigmine (5, 10, 20, and 50 micrograms x kg(-1)) or edrophonium (100, 200, 400, and 1,000 micrograms x kg(-1)) or placebo was given, by random allocation, when T1 had recovered to 10%. Values of T1 and train-of-four were measured for 10 min. Spontaneous recovery proceed...Continue Reading

References

Feb 1, 1989·Anesthesiology·N G GoudsouzianJ J Savarese
Apr 1, 1989·Anesthesia and Analgesia·D R CookR M Welch
Sep 1, 1986·Canadian Anaesthetists' Society Journal·R K Mirakhur
Jun 1, 1983·British Journal of Anaesthesia·J EngbaekJ Viby-Mogensen
Jun 1, 1983·British Journal of Anaesthesia·J EngbaekJ Viby-Mogensen
Oct 1, 1984·Anesthesiology·D M FisherR D Miller
Jan 1, 1982·Canadian Anaesthetists' Society Journal·R K MirakhurR S Clarke
Nov 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J C BevanD R Bevan

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Citations

Aug 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M R LessardJ F Rouillard
Nov 18, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Takahiro SuzukiJohn J Savarese
May 27, 2009·British Journal of Anaesthesia·A Srivastava, J M Hunter
Mar 11, 1999·Anesthesia and Analgesia·C A LienJ J Savarese
Jun 24, 2003·Anesthesia and Analgesia·Yaakov BeilinCarol Bodian
Jul 23, 2003·Anesthesia and Analgesia·Julia E PollockNayak L Polissar
Dec 15, 2018·Acta Anaesthesiologica Scandinavica·Joakim Holger Waage BrinchMatias Vested Madsen

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