Dose selection for radioiodine therapy of borderline hyperthyroid patients with multifocal and disseminated autonomy on the basis of 99mTc-pertechnetate thyroid uptake

European Journal of Nuclear Medicine and Molecular Imaging
Michael J ReinhardtThomas M Krause

Abstract

The aim of this study was to optimise radioiodine therapy of diffuse and nodular toxic goitre by calculation of the radiation dose delivered to the thyroid on the basis of the pretreatment technetium-99m pertechnetate thyroid uptake under thyrotropin suppression (TcTU(s)). The TcTU(s) value serves as a substitute for the non-suppressible iodine turnover and the functional autonomous mass. Marinelli's formula was used to calculate tissue absorbed doses of 150 Gy, 200 Gy, 250 Gy and 300 Gy to the thyroids of 438 patients with multifocal and disseminated autonomy. The mean age of patients was 70+/-9 years, and the mean thyroid volume was 54+/-26 ml. Two hundred and sixty-one of the patients had at least one documented previous episode of overt hyperthyroidism. Tissue absorbed doses were adapted to the pretreatment TcTU(s): 150 Gy for a TcTU(s) of 1.5%-2.49%, 200 Gy for a TcTU(s) of 2.5%-3.49%, 250 Gy for a TcTU(s) of 3.5%-4.49% and 300 Gy for a TcTU(s) of > or =4.5%. Normalisation of TcTU(s) and thyrotropin (TSH), thyroid volume reduction and frequency of hypothyroidism and recurrent hyperthyroidism were evaluated 1 year after a single radioiodine therapy. The presented dose strategy resulted in normalisation of TcTU(s) in 96% and...Continue Reading

Citations

Jul 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Marcel P M StokkelMarkus Luster
Feb 8, 2013·Medical Physics·José WillegaignonCarlos A Buchpiguel
Mar 19, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Jérôme Clerc
Apr 28, 2006·Clinical Physiology and Functional Imaging·Ulrik Sloth KristoffersenAndreas Kjaer
Dec 7, 2016·Nuklearmedizin. Nuclear Medicine·Markus DietleinMarkus Luster
Nov 21, 2018·HNO·H GraefeJ E Meyer
Feb 23, 2013·Clinical Nuclear Medicine·José WillegaignonCarlos Alberto Buchpiguel
Feb 11, 2021·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Jérôme Clerc

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