Dose-time-response association between occupational asbestos exposure and pleural mesothelioma

Occupational and Environmental Medicine
Aude LacourtKaren Leffondré

Abstract

Early occupational exposure to asbestos has been shown to be associated with an increased risk of pleural mesothelioma (PM), which suggests that the timing of exposure might play a role in the dose-response relationship. However, none studies has evaluated the relative impact of increasing the annual intensity of occupational exposure to asbestos at each time of the whole exposure history. Yet such evaluation would allow the comparison of the risks of PM associated with different longitudinal profiles of occupational exposure to asbestos. Our objective was to estimate the time-dependent relative impact of asbestos exposure intensity over the whole occupational history and to compare the resulting estimated risks of PM associated with different profiles of exposure, using data from a large French case-control study. This study included 1196 male cases recruited in 1987-2006 and 2369 matched controls on birth year. Occupational exposure to asbestos was assessed using a job exposure matrix and represented in logistic regression models using a flexible weighted cumulative index of exposure. Due to much stronger weights of early doses of asbestos exposure, subjects who accumulated 20 fibres/mL over their entire job history with high...Continue Reading

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Citations

Aug 22, 2017·Occupational and Environmental Medicine·Paolo BoffettaCarlo La Vecchia
Jan 17, 2019·Expert Review of Respiratory Medicine·Edward J A HarrisFraser J H Brims
Mar 21, 2019·Radiology and Oncology·Kristina LevpuscekAlenka Franko
Mar 15, 2019·Journal of Occupational and Environmental Medicine·Francesco CuccaroCorrado Magnani
Oct 25, 2017·Occupational and Environmental Medicine·Aude LacourtKaren Leffondre
Aug 5, 2020·European Journal of Public Health·Alberto ScarselliSergio Iavicoli
Feb 6, 2021·Radiology and Oncology·Alenka FrankoVita Dolzan
Oct 28, 2019·EBioMedicine·Nicolas AlcalaLynnette Fernandez-Cuesta

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