Dose-volume analysis and the temporal nature of toxicity with stereotactic body radiation therapy for prostate cancer

Practical Radiation Oncology
Zachary A SeymourAlexander R Gottschalk

Abstract

The purpose of this study was to evaluate the dose-volume relationships of genitourinary toxicity after stereotactic body radiation therapy (SBRT) monotherapy for prostate cancer. Fifty-six patients diagnosed with low- to intermediate-risk prostate cancer treated with SBRT alone were reviewed retrospectively. All patients received a total dose of 38 Gy in 4 fractions with a planning target volume expansion of 2 mm. Overall, acute, and late genitourinary toxicity were documented according to the Common Terminology Criteria for Adverse Events (version 4) and International Prostate Symptom Scores (IPSS). The median age at treatment was 68 years, and the median prostate volume was 45.5 mL, with a median baseline IPSS of 9.95. The median prescription isodose line was 68%. The median clinical follow-up was 35.49 months. Acute grade 1, 2, and 3 genitourinary toxicities occurred in 41.1%, 35.7%, and 0% of patients. All acute genitourinary toxicities resolved except 1 patient with grade 2 toxicity that progressed to grade 3 late toxicity. No dose-volume relationships were associated with acute genitourinary grade 2+ toxicity. Late grade 1, 2, and 3 genitourinary toxicity occurred in 19.6%, 19.6%, and 3.6% of cases, respectively. Of the ...Continue Reading

References

Aug 30, 2008·International Journal of Radiation Oncology, Biology, Physics·Christopher R KingJoseph C Presti
Dec 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Siavash JabbariAlexander R Gottschalk
Feb 9, 2011·International Journal of Radiation Oncology, Biology, Physics·Christopher R KingJoseph C Presti
Apr 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas P BoikeRobert Timmerman
Jun 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Ivan R Vogelius, Søren M Bentzen
Sep 26, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christopher R KingAlan Katz
Mar 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James B YuCary P Gross
Mar 14, 2014·Practical Radiation Oncology·I-Chow HsuHoward Sandler

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Citations

Oct 16, 2015·The British Journal of Radiology·Amar U KishanMitchell Kamrava
Oct 18, 2016·The British Journal of Radiology·Tejinder KatariaNisha T Vishnu
Feb 24, 2018·Medical Physics·Dale W LitzenbergDaniel E Spratt
Jul 22, 2016·The Cancer Journal·Jonathan W LischalkSean P Collins
Dec 29, 2020·International Journal of Radiation Oncology, Biology, Physics·Kyle WangRonald C Chen

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