Dosimetric Benefits and Practical Pitfalls of Daily Online Adaptive MRI-Guided Stereotactic Radiation Therapy for Pancreatic Cancer

Practical Radiation Oncology
Nancy El-BaredEric A Mellon

Abstract

Magnetic resonance imaging guided (MRI-g) radiation therapy provides visualization of the target and organs at risk (OARs), allowing for daily online adaptive radiation therapy (OART). We hypothesized that MRI-g OART would improve OAR sparing and target coverage in patients with pancreatic cancer treated with stereotactic body radiation therapy (SBRT). Ten patients received pancreas SBRT to a dose of 33 to 40 Gy in 5 fractions. The dose was prescribed to 90% coverage of the planning target volume at 100% isodose (PTV100). After each fraction's setup magnetic resonance imaging scan, the target position was aligned by 3-dimensional shifts, the normal anatomy was recontoured, and the original radiation therapy plan was recalculated to create a nonadaptive plan. A reoptimized (adaptive) plan was then generated for each fraction and renormalized to 90% coverage of PTV100. Target and OAR doses between nonadaptive and adaptive plans were compared to assess the dosimetric impact of daily adaptation. The PTV100 mean for adaptive and nonadaptive techniques was 90% and 80.4% (range, 46%-97%), respectively (P = .0008). Point maximum (Dmax) 38 Gy duodenum objectives were met in 43 adaptive fractions compared with 32 nonadaptive fractions (P...Continue Reading

Citations

Aug 21, 2019·The British Journal of Radiology·Ann RaldowTheodore Hong
Feb 14, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leila T TchelebiRodney J Ellis
Mar 15, 2020·Journal of Applied Clinical Medical Physics·Niclas PetterssonLaura I Cerviño
Jun 15, 2020·Molecular Oncology·Vincent GrégoireDaniel Zips
Oct 28, 2019·Journal of Medical Imaging and Radiation Oncology·Stephen ChinAnanya Choudhury
Aug 14, 2020·The British Journal of Radiology·Leif-Erik D SchumacherEric A Mellon
Oct 30, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Leila T TchelebiMichael D Chuong
Jan 16, 2021·Journal of Applied Clinical Medical Physics·Maureen LeeMichael Velec
Jan 21, 2021·International Journal of Radiation Oncology, Biology, Physics·Carri K Glide-HurstEvan Wuthrick
Oct 16, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·William A HallUNKNOWN MR Linac Atlantic Consortium and the ViewRay C2T2 Research Consortium
Mar 26, 2021·Frontiers in Oncology·Danilo MazieroEric A Mellon
Aug 21, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A BriensR De Crevoisier
Aug 27, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D PasquierE Lartigau
Apr 4, 2021·International Journal of Radiation Oncology, Biology, Physics·Alba Magallon-BaroMischa S Hoogeman
Sep 2, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Fabian WeykampJuliane Hörner-Rieber
Sep 22, 2021·Radiation Oncology·Francesco CucciaStefanie Corradini
Nov 3, 2021·Molecular Cancer Therapeutics·Taha YazalErina Vlashi

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