Dosimetric comparison of volume-based and inverse planning simulated annealing-based dose optimizations for high-dose rate brachytherapy

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Satish PelagadeJ P Neema

Abstract

The aim of this study was to compare the clinical benefits of inverse planning simulated annealing (IPSA)-based optimization over volume-based optimization for high-dose rate (HDR) cervix interstitial implants. Overall, 10 patients of cervical carcinoma were considered for treatment with HDR interstitial brachytherapy. Oncentra Master Plan brachytherapy planning system was used for generating 3-dimensional HDR treatment planning for all patients. All patient treatments were planned using volume-based optimization and inverse planning optimization (IPSA). The parameters V100, V150, and V200 for the target; D(2 cm³) of bladder, rectum, and sigmoid colon; and V80 and V100 for bladder, rectum, and sigmoid colon were compared using dose-volume histograms (DVHs). The conformity index (CI), relative dose homogeneity index, overdose volume index (ODI), and dose nonuniformity index (DNR) were computed from cumulative DVHs. Good target coverage for prescription dose was achieved with volume-based optimization as compared with IPSA-based dose optimization. Homogeneity was good with the IPSA-based technique as compared with the volume-based dose optimization technique. Volume-based optimization resulted in a higher CI (with a mean value of...Continue Reading

References

Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·C B Saw, N Suntharalingam
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·P KneschaurekR Wehrmann
Feb 14, 2009·Brachytherapy·Fumiaki IsohashiTakehiro Inoue

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Citations

Aug 11, 2018·Physics in Medicine and Biology·Gabriel FamulariShirin A Enger

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