Dosimetric comparison of Y90, P32, and Re186 radiocolloids in craniopharyngioma treatments

Medical Physics
Mahdi SadeghiS Hamed Hosseini

Abstract

In the radionuclide treatment of some forms of brain tumors such as craniopharyngiomas, the selection of the appropriate radionuclide for therapy is a key element in treatment planning. The aim was to study the influence by considering the beta-emitter radionuclide dose rate in an intracranial cyst. Dosimetry was performed using the MCNP4C radiation transport code. Analytical dosimetry was additionally performed using the Loevinger and the Berger formulas in the MATLAB software. Each result was compared under identical conditions. The advantages and disadvantages of using Y90 versus P32 and Re186 were investigated. The dose rate at the inner surface of the cyst wall was estimated to be400mGy∕h for a 1MBq∕ml concentration of Y90. Under identical conditions of treatment, the corresponding dose rates were 300mGy∕h for P32 and 160mGy∕h for Re186. For a well-defined cyst radius and identical wall thickness, higher dose rates resulted for Y90. To achieve the same radiological burden, the required amount of physical activity of injectable solution is lower forP32. This is found to be a consequence of both the radionuclide physical half-life and the pattern of energy deposition from the emitted radiation. According to the half-life and...Continue Reading

References

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Citations

Jul 11, 2018·Australasian Physical & Engineering Sciences in Medicine·Maryam BabaeiSohrab Shahzadi
Jan 15, 2015·Physics in Medicine and Biology·H TreuerJ Wirths

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