Dosimetric effects of dose calculation grid size on the epidural space dose.

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Hidetoshi ShimizuTakeshi Kodaira

Abstract

The epidural disease progression is the most common pattern of failure after spine stereotactic body radiotherapy. The aim of this study was to clarify the effect of the dose calculation grid size (CGS) during volumetric modulated arc therapy planning on the dose to the epidural space target. In the planning, the volume obtained by subtracting the planning organ at risk volume (PRV) of the spinal cord and/or cauda equina from the planning target volume (PTV) was defined as the PTVeval. First, we compared the epidural space dose that overlapped with the PTVeval at dose CGSs of 1 mm and 2 mm. Next, we compared the dose that can be given, according to the isotropic distance from the PRV of the spinal cord and/ or cauda equina at dose CGSs of 1 mm and 2 mm. The dose to the epidural space overlapping with the PTVeval was significantly larger at the dose CGS of 1 mm (60 to 80 cGy, 3% of the prescription dose) than at the dose CGS of 2 mm (p < 0.01). In addition, compared with the dose CGS of 2 mm, the dose CGS of 1 mm provided a larger dose to 95% of the volume in the regions where the PTVeval overlapped at isotropic distances of 0 to < 1, 1 to 2, 2 to 3, 3 to 4, and 4 to 5 mm from the PRV of the spinal cord and/or cauda equina. Duri...Continue Reading

References

Dec 20, 2008·International Journal of Radiation Oncology, Biology, Physics·Arjun SahgalDavid A Larson
Sep 22, 2009·International Journal of Radiation Oncology, Biology, Physics·Arjun SahgalDavid A Larson
Sep 3, 2010·Journal of Neurosurgery. Spine·Mark H BilskyTimothy R Kuklo
Oct 1, 2010·Medical Physics·Stanley H BenedictFang-Fang Yin
Oct 19, 2010·International Journal of Radiation Oncology, Biology, Physics·Arjun SahgalDavid A Larson
Sep 21, 2011·Medical Physics·Chin Loon OngWilko F A R Verbakel
May 23, 2012·International Journal of Radiation Oncology, Biology, Physics·Brett W CoxYoshiya Yamada
Sep 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Isabelle ThibaultArjun Sahgal
Nov 17, 2016·Practical Radiation Oncology·Shiv P SrivastavaIndra J Das
Mar 18, 2017·Surgical Neurology International·Michael HuoMatthew Foote
Jul 15, 2017·Journal of Neurosurgery. Spine·Sten MyrehaugAntonio De Salles
Sep 30, 2017·Journal of Applied Clinical Medical Physics·Kelly C YoungeMartha M Matuszak
Jan 20, 2018·Journal of Applied Clinical Medical Physics·Matthew MalloryFen Wang
Feb 9, 2018·Journal of Applied Clinical Medical Physics·Saif AljababShawn Malone
May 29, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christos MoustakisOliver Blanck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.