Dosimetric impact of prostate volume change between CT-based HDR brachytherapy fractions

International Journal of Radiation Oncology, Biology, Physics
Yongbok KimJean Pouliot

Abstract

The objective is to evaluate the prostate volume change and its dosimetric consequences after the insertion of catheters for high-dose-rate brachytherapy. For 13 consecutive patients, a spiral CT scan was acquired before each of the 2 fractions, separated on average by 20 hours. The coordinates of the catheters were obtained on 3 axial CT slices corresponding to apex, mid portion, and base portion of the prostate. A mathematical expansion model was used to evaluate the change of prostate volumes between the 2 fractions. It is based on the difference in the cube of the average distance between the centroid and catheter positions. The variation of implant dose-volume histograms between fractions was computed for plans produced by either inverse planning based on simulated annealing or geometric optimization. The average magnitude of either increase or reduction in prostate volume was 7.8% (range, 2-17%). This volume change corresponds to an average prostate radius change of only 2.5% (range, 0.7-5.4%). For 5 patients, the prostate volume increased on average by 9% (range, 2-17%), whereas a reduction was observed for 8 patients by an average of 7% (range, 2-13%). More variation was observed at the prostate base than at mid or apex...Continue Reading

References

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Citations

Jun 10, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Markus Karl Alfred HerrmannAndrea Hille
Jul 13, 2006·Prostate Cancer and Prostatic Diseases·O Al-SalihiH Payne
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Nov 18, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tom BudihartoKarin Haustermans
Dec 18, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yongbok KimJean Pouliot
Jul 7, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·G C Morton
Dec 8, 2014·Australasian Physical & Engineering Sciences in Medicine·Ryan L SmithJeremy L Millar
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anna M DinklaArjan Bel
Feb 8, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Inger-Karine K Kolkman-DeurlooShafak Aluwini
Jun 20, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Ryan L SmithRick D Franich

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