Dosimetric selection for helical tomotherapy based stereotactic ablative radiotherapy for early-stage non-small cell lung cancer or lung metastases.

PloS One
Alexander ChiRitsuko Komaki

Abstract

No selection criteria for helical tomotherapy (HT) based stereotactic ablative radiotherapy (SABR) to treat early stage non-small cell lung cancer (NSCLC) or solitary lung metastases has been established. In this study, we investigate the dosimetric selection criteria for HT based SABR delivering 70 Gy in 10 fractions to avoid severe toxicity in the treatment of centrally located lesions when adequate target dose coverage is desired. 78 HT-SABR plans for solitary lung lesions were created to prescribe 70 Gy in 10 fractions to the planning target volume (PTV). The PTV was set to have ≥95% PTV receiving 70 Gy in each case. The cases for which dose constraints for ≥1 OAR could not be met without compromising the target dose coverage were compared with cases for which all target and OAR dose constraints were met. There were 23 central lesions for which OAR dose constraints could not be met without compromising PTV dose coverage. Comparing to cases for which optimal HT-based SABR plans were generated, they were associated with larger tumor size (5.72±1.96 cm vs. 3.74±1.49 cm, p<0.0001), higher lung dose, increased number of immediately adjacent OARs ( 3.45±1.34 vs. 1.66±0.81, p<0.0001), and shorter distance to the closest OARs (GTV:...Continue Reading

References

Aug 1, 2002·Medical Physics·Wolfgang A Tomé, Jack F Fowler
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Rikiya OnimaruHirotoshi Dosaka-Akita
Jun 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Tingyi XiaJoe Y Chang
Aug 4, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·George RodriguesTomas Kron
Oct 3, 2006·Seminars in Radiation Oncology·John D FenwickT Rock Mackie
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Dec 22, 2006·Physics in Medicine and Biology·Brian KanagakiKe Sheng
Jul 19, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hiroshi OnishiTsutomu Araki
Jan 12, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Florian SterzingKlaus Herfarth
Aug 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Giovanni Mauro CattaneoRiccardo Calandrino
Jan 27, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Si Yeol SongEun Kyung Choi
Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Achilles J FakirisRobert Timmerman
Mar 31, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael T MilanoPaul Okunieff
Sep 22, 2009·International Journal of Radiation Oncology, Biology, Physics·Arjun SahgalDavid A Larson
Nov 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Florian SterzingGustavo Oliveira
Jan 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alexander ChiRitsuko Komaki
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·John P KirkpatrickTimothy E Schultheiss
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
May 4, 2010·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Alonso N GutiérrezNiko Papanikolaou
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yoshiko OshiroJun Itami
Jan 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Alexander ChiRitsuko Komaki
Feb 2, 2011·International Journal of Radiation Oncology, Biology, Physics·Yasushi NagataBranislav Jeremic
May 17, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael C StauderYolanda I Garces
Jun 1, 2011·Frontiers of Radiation Therapy and Oncology·Robert TimmermanJohn L Meyer
Jul 6, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Umberto RicardiGiorgio Vittorio Scagliotti
Nov 8, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Heike PeulenPeter Wersäll

❮ Previous
Next ❯

Methods Mentioned

BETA
Hi-Art
X-ray

Software Mentioned

Google scholar
QUNTEC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.