Dosimetry and Toxicity Studies of the Novel Sulfonamide Derivative of Sulforhodamine 101([18F]SRF101) at a Preclinical Level

Current Radiopharmaceuticals
Ingrid KreimermanHenry Engler

Abstract

The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to estimate human radiation dosimetry based on preclinical studies. Radiation dosimetry studies were conducted based on biokinetic data obtained from a mouse model. A single-dose toxicity study was carried out. The toxicological limit chosen was <100 μg, and allometric scaling with a safety factor of 100 for unlabelled SRF101 was selected. The absorbed and effective dose estimated using OLINDA/EXM V2.0 for male and female dosimetric models presented the same tendency. The highest total absorbed dose values were for different sections of the intestines. The mean effective dose was 4.03 x10-3 mSv/MBq and 5.08 x10-3 mSv/MBq for the male and female dosimetric models, respectively, using tissue-weighting factors from ICRP-89. The toxicity study detected no changes in the organ or whole-body weight, food consumption, haematologic or clinical chemistry parameters. Moreover, lesions or abnormalities were not fou...Continue Reading

References

Mar 23, 2005·Nature Methods·Axel NimmerjahnFritjof Helmchen
Aug 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Rikki N WaterhouseJon C Mirsalis
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexei VerkhratskyJose Julio Rodriguez
Mar 15, 2011·Neurobiology of Disease·Sameh K Wasseff, Steven S Scherer
Sep 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael G StabinMichael J Fernald
Oct 31, 2014·Nature Methods·Robert A Hill, Jaime Grutzendler
Dec 15, 2015·EJNMMI Research·Morvarid KarimiRichard Laforest
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
Jun 23, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Stefano BoschiKen Herrmann
Sep 7, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mathias KranzOsama Sabri
Mar 16, 2017·Frontiers in Cellular Neuroscience·Swen HülsmannChristian Schnell
Sep 10, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael G Stabin, Jeffry A Siegel
Sep 29, 2017·Current Radiopharmaceuticals·Ingrid KreimermanHenry Engler
Feb 8, 2018·Nuclear Medicine and Biology·Anne-Sophie SalabertPierre Payoux
Jan 1, 2017·EJNMMI Radiopharmacy and Chemistry·J KoziorowskiT L Mindt

❮ Previous
Next ❯

Citations

Jan 8, 2022·Bioconjugate Chemistry·Julen AriztiaBertrand Kuhnast

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
C BrihayeD Comar
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Rikki N WaterhouseJon C Mirsalis
© 2022 Meta ULC. All rights reserved