PMID: 11606807Oct 19, 2001Paper

Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment

Toxicological Sciences : an Official Journal of the Society of Toxicology
J S KimbellF J Miller

Abstract

Interspecies extrapolations of tissue dose and tumor response have been a significant source of uncertainty in formaldehyde cancer risk assessment. The ability to account for species-specific variation of dose within the nasal passages would reduce this uncertainty. Three-dimensional, anatomically realistic, computational fluid dynamics (CFD) models of nasal airflow and formaldehyde gas transport in the F344 rat, rhesus monkey, and human were used to predict local patterns of wall mass flux (pmol/[mm(2)-h-ppm]). The nasal surface of each species was partitioned by flux into smaller regions (flux bins), each characterized by surface area and an average flux value. Rat and monkey flux bins were predicted for steady-state inspiratory airflow rates corresponding to the estimated minute volume for each species. Human flux bins were predicted for steady-state inspiratory airflow at 7.4, 15, 18, 25.8, 31.8, and 37 l/min and were extrapolated to 46 and 50 l/min. Flux values higher than half the maximum flux value (flux median) were predicted for nearly 20% of human nasal surfaces at 15 l/min, whereas only 5% of rat and less than 1% of monkey nasal surfaces were associated with fluxes higher than flux medians at 0.576 l/min and 4.8 l/mi...Continue Reading

References

Aug 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M CasanovaH D Heck
Jan 1, 1991·Annual Review of Pharmacology and Toxicology·R B Conolly, M E Andersen
Dec 1, 1990·Scandinavian Journal of Work, Environment & Health·A BlairC Shy
Sep 1, 1989·Archives of Environmental Health·W C AdamsJ D Shaffrath
Sep 1, 1987·Toxicology Letters·M S BogdanffyK T Morgan
Jan 1, 1981·Respiration Physiology·V NiinimaaR J Shephard
Feb 1, 1993·Scandinavian Journal of Work, Environment & Health·T Partanen
Jul 1, 1997·Journal of Occupational and Environmental Medicine·J J CollinsN A Esmen
Aug 1, 1997·Toxicology and Applied Pharmacology·J S KimbellK T Morgan
Jun 19, 1998·Toxicology and Applied Pharmacology·G M KeplerJ S Kimbell
Jun 19, 1998·Toxicology and Applied Pharmacology·M L BushJ S Ultman
Sep 25, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·M S BogdanffyM E Andersen
Oct 19, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J S KimbellK T Morgan
Oct 19, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J H OvertonF J Miller

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Citations

Oct 15, 2009·Annals of Biomedical Engineering·Geng Tian, P Worth Longest
Oct 5, 2007·Bulletin of Mathematical Biology·Karen A YokleyPaul M Schlosser
May 9, 2012·Bulletin of Mathematical Biology·Karen A Yokley
Dec 31, 2002·Toxicology·Rory B Conolly
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part a·Michael FirestoneTracey Woodruff
Jul 17, 2008·The Annals of Occupational Hygiene·Kenny S CrumpRavi Subramaniam
Jan 29, 2009·The Annals of Occupational Hygiene·Rory B ConollyDerek Janszen
Oct 19, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J H OvertonF J Miller
Feb 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kun LuJames A Swenberg
May 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard A CorleyDaniel R Einstein
Feb 1, 1997·Risk Analysis : an Official Publication of the Society for Risk Analysis·D A Kramer, R B Conolly
May 13, 2010·Journal of Biomechanical Engineering·Geng Tian, P Worth Longest
Dec 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephan A CareyJack R Harkema
Jan 5, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffry D SchroeterMelvin E Andersen
Oct 17, 2009·Inhalation Toxicology·Guilherme J M Garcia, Julia S Kimbell
May 23, 2009·Inhalation Toxicology·Guilherme J M GarciaJulia S Kimbell
Dec 4, 2003·Inhalation Toxicology·Anna V GeorgievaPaul M Schlosser
Feb 23, 2011·Journal of Aerosol Science·Jeffry D SchroeterJulia S Kimbell
Jan 17, 2009·Advanced Drug Delivery Reviews·Randall J Mrsny
Apr 9, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Per Gerde
Jun 21, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·Ravi P SubramaniamPaul White
Nov 10, 2015·Journal of Occupational and Environmental Hygiene·Eileen D KuempelAnnie M Jarabek
Sep 29, 2015·Critical Reviews in Toxicology·Kenneth T Bogen, Jacqueline M Heilman
Feb 16, 2002·Regulatory Toxicology and Pharmacology : RTP·R B ConollyF J Miller
Dec 14, 2007·Risk Analysis : an Official Publication of the Society for Risk Analysis·Ravi P SubramaniamPaul M Schlosser
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part a·Gary L GinsbergAnnie M Jarabek
Sep 6, 2011·Inhalation Toxicology·Frederick J MillerRory B Conolly
Jun 24, 2017·Pharmaceutical Research·P Worth Longest, Michael Hindle
Feb 7, 2018·Inhalation Toxicology·Frederick J MillerJulia S Kimbell
May 22, 2020·Tobacco Induced Diseases·Jeffrey EbersoleAndrey Khlystov

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