PMID: 8946374Oct 1, 1996Paper

Dosimetry of a radioactive coronary balloon dilatation catheter for treatment of neointimal hyperplasia

Medical Physics
H AmolsJ Weinberger

Abstract

Recent reports suggest that intraluminal irradiation of coronary arteries in conjunction with balloon angioplasty reduces proliferation of smooth muscle cells and neointima formation, thereby inhibiting restenosis. One possible irradiation technique is to inflate the balloon dilitation catheter with a radioactive solution. This has advantages over other proposed irradiation procedures, in that accurate source positioning and uniform dose to the vessel wall are assured. Several high-energy beta-minus emitters may be suitable for this application. We present experimental measurements and analytical calculations of the dose distribution around a 3-mm-diam by 20-mm-long balloon filled with 90Y-chloride solution. The dose rate at the surface of the balloon is approximately 0.14 cGy/s per mCi/ml (3.78 x 10(-11) Gy/s per Bq/ml), with the dose decreasing to 53% at 0.5 mm, and < 5% at 3.5-mm radial distance. 90Y and other possible isotopes are currently available at specific concentrations > or = 50 mCi/ml (1.85 x 10(9) Bq/ml), which enables the delivery of 20 Gy in less than 5 min. The dosimetric and radiation safety advantages of this system warrant further feasibility studies. Issues of concern include incorporating the beta-emitter ...Continue Reading

Citations

Jan 5, 2002·Australasian Physical & Engineering Sciences in Medicine·R A Fox
Jan 11, 2008·Cardiovascular and Interventional Radiology·Walter A WohlgemuthKlaus Kirchhof
Sep 7, 2000·International Journal of Radiation Oncology, Biology, Physics·R C ChanR Waksman
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·A M JoussenB Kirchhof
Aug 31, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Usha PandeyMeera Venkatesh
Jun 9, 1998·Journal of Vascular and Interventional Radiology : JVIR·D A Diamond, T M Vesely
Apr 3, 2001·Health Physics·R J Fry
Aug 27, 2002·Nuclear Medicine Communications·Jörg KotzerkeM Höher
Mar 29, 2001·Cardiovascular Radiation Medicine·H I Amols
Mar 29, 2001·Cardiovascular Radiation Medicine·S K Jani
Mar 29, 2001·Cardiovascular Radiation Medicine·H I Amols
Jun 26, 2004·Current Opinion in Cardiology·John P Reilly, Steven R Ramee
Mar 1, 1997·Medical Physics·C JanickiT A Fischell
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Dec 29, 2000·Physics in Medicine and Biology·R A Fox, P W Henson
Aug 16, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Martin WernerMatthias Gutberlet

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