PMID: 9430482Jan 16, 1998Paper

Dosimetry of pediatric radiopharmaceuticals: uniformity of effective dose and a simple aid for its estimation

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
T SmithI Gordon

Abstract

Formulae were investigated for predicting the effective dose to children, per unit administered activity of various pediatric radiopharmaceuticals, based only on the weight of the patient. Their influence on the uniformity of effective dose from total administered activity was also examined. The formulae were obtained from calculations of effective dose per unit administered activity (mSv x MBq[-1]) for five anthropomorphic mathematical phantoms applicable for newborn, 1-yr-, 5-yr-, 10-yr- and 15-yr-old children, having body weights of 3.4, 9.8, 19, 32 and 57 kg, respectively, using published biokinetic models. In general, there was good linear correlation between effective dose per unit administered activity and inverse weight but, for some radiopharmaceuticals, logarithmic regression on weight provided a better fit to the data. An administered activity schedule based on body surface area, used with these formulae, resulted in reasonable uniformity of effective dose for children of all ages, with varying degrees of uniformity for different radiopharmaceuticals (coefficient of variation (COV) up to 20%). Individual activity schedules for separate radiopharmaceuticals gave best uniformity (COV < 7%) while a single general schedu...Continue Reading

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