Dosing patterns and costs of tumor necrosis factor inhibitor use for rheumatoid arthritis

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
David J HarrisonDenise Globe

Abstract

Differences in dosing patterns and costs among patients with rheumatoid arthritis (RA) treated with the tumor necrosis factor (TNF) inhibitors etanercept, adalimumab, and infliximab were analyzed on the basis of claims data. Commercial health insurance claims data from January 2004 through December 2005 from the PharMetrics Patient-centric Database were analyzed. Adults (> or =18 years of age) with RA with a minimum of two claims for the same TNF inhibitor within a 12-month period and with at least 18 months of continuous enrollment in the database (encompassing a 6-month preindex period and a 12-month follow-up period) were included. Patients were considered treatment naive if they had no claims for a TNF inhibitor during the preindex period; continuing patients had at least one TNF-inhibitor claim during the preindex period. A total of 845 treatment-naive and 3783 continuing patients were included. Medication use, costs, and health care use were generally similar among the treatment groups in the preindex period for both naive and continuing patients. Among both naive and continuing patients, dose increases from the first to the last prescription were most likely to occur in the infliximab group (26% and 24%, respectively) co...Continue Reading

References

Jun 18, 2004·The New England Journal of Medicine·James R O'Dell
Jun 7, 2005·Journal of Managed Care Pharmacy : JMCP·Daniel A OllendorfSomali Misra Burgess
Mar 30, 2007·Annals of the Rheumatic Diseases·Mahboob U RahmanRene Westhovens
Dec 17, 2008·Annals of the Rheumatic Diseases·D E FurstM H Weisman
Oct 20, 2009·European Journal of Pharmacology·Freddy Cornillie

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Citations

Sep 25, 2015·Journal of Medical Economics·J HarnettJ Bourret
May 15, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·Julio Martinez-CutillasAmelia Sánchez-Guerrero
Feb 2, 2015·Rheumatology International·Rafael Ferriols-Lisart, Francisco Ferriols-Lisart
Jul 25, 2017·Journal of Managed Care & Specialty Pharmacy·Thomas DelateDaniel Jenkins
Aug 10, 2017·Journal of Comparative Effectiveness Research·Anagha NadkarniDavid Smith
May 6, 2017·Clinical Rheumatology·Sergio SchwartzmanJacqueline B Palmer
Sep 7, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Konstantinos KotsisThomas Hyphantis
Jul 21, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Alan ReynoldsAmitabh Singh

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