Dot-like hemosiderin spots on gradient echo T2*-weighted magnetic resonance imaging are associated with past history of small vessel disease in patients with intracerebral hemorrhage

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Toshio ImaizumiJun Niwa

Abstract

Lipohyalinosis is considered an important cause of cerebral small vessel disease (SVD), including hypertensive intracerebral hematoma (ICH) and lacunar infarction. Dot-like low-intensity spots (dot-like hemosiderin spots [dotHSs]) on gradient-echo T2*-weighted (T2*-w) magnetic resonance imaging (MRI) have been histologically diagnosed as old microbleeds associated with microangiopathies (lipohyalinosis, amyloid angiopathy) and located in territories of perforating arteries (deep dotHSs) and subcortical regions (subcortical dotHSs). If dotHSs indicate the severity of lipohyalinosis, larger numbers of deep dotHSs may be associated with past history of SVD. The number of dotHSs was investigated in 213 patients with deep ICH (106 men, 107 women, 37 to 94 years old, mean age = 65.8 +/- 11.2 years). Patients were divided into 2 subgroups according to past history of SVD. Odds ratio (OR) for the history was estimated from logistic regression analyses of the number of deep or subcortical dotHSs, as well as other factors. Of 213 patients, 36 had a past history of SVD (symptomatic deep ICH in 18, symptomatic lacunar infarction in 17, and both in 1). An increased rate of history of SVD was found for patients with subcortical dotHSs. The O...Continue Reading

Citations

Aug 26, 2004·Journal of the International Neuropsychological Society : JINS·Erin D Bigler
Nov 26, 2010·Current Neurology and Neuroscience Reports·Thalia S Field, Oscar R Benavente
Feb 27, 2010·La Presse médicale·Philippe Goas, Serge Timsit
May 12, 2009·European Journal of Radiology·Sabine Weckbach, Stefan O Schoenberg
Aug 11, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Akira Watanabe
Jul 29, 2006·Magnetic Resonance Imaging Clinics of North America·Harold Keyserling, Srinivasan Mukundan
Jan 31, 2006·Neuroimaging Clinics of North America·Harold Keyserling, Srinivasan Mukundan
Jan 15, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Toshio ImaizumiJun Niwa
Jul 29, 2009·Klinische Neuroradiologie·Jennifer Linn, Hartmut Brückmann

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