DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines

Biochimie
Dulamsuren OktyabriTakeshi Suzuki

Abstract

DOT1L is a histone H3 lysine 79 (H3K79) methyltransferase mainly implicated in leukemia. Here we analyzed the function of DOT1L in breast cancer cells. The expression of DOT1L was up-regulated in malignant breast cancer tissues. Over-expression of DOT1L significantly increased the sphere formation and the cell migration activities of MCF7 breast cancer cell line. In contrast, knockdown of DOT1L reduced the cell migration activity of MDA-MB-231 breast cancer cell line. BCAT1, which encodes a branched-chain amino acid transaminase, was identified as one of the target genes controlled by DOT1L through the regulation of H3K79 methylation. Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L-mediated sphere formation and cell migration in breast cancer cells.

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Citations

Dec 7, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Elitsa A Ananieva, Adam C Wilkinson
Nov 30, 2018·Annual Review of Physiology·Michael NeinastZoltan Arany
Jul 9, 2020·Antioxidants & Redox Signaling·Myra Elizabeth Conway
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May 23, 2017·Molecular and Clinical Oncology·Heike LoeserAlexander Quaas
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Dec 29, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mai Ahmed ShafeiMyra E Conway
Apr 3, 2021·Seminars in Cancer Biology·Jae Eun Lee, Mi-Young Kim
Oct 2, 2021·Frontiers in Cell and Developmental Biology·Wei LiDa Pang

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