PMID: 374446Mar 1, 1979Paper

Double-blind and triple-blind assessments of medication and placebo responses in hyperactive children

Journal of Abnormal Child Psychology
B HenkerB E Collins

Abstract

Hyperactive boys taking psychostimulant medication were studied using a randomized, placebo-controlled, crossover design. Behavior ratings and medication guesstimates were obtained for the boys when they were given methylphenidate (Ritalin) and when they were given a placebo. The ratings showed positive medication-related changes, and the guesses, done by independent judges, were significantly better than chance. The pattern of ratings for double-blind and triple-blind raters was identical. These results imply that positive psychostimulant effects are not attributable to rater sensitization or expectancy. The medication-placebo differences were highly reliable for the group comparisons and were in the predicted direction for 21 of 22 individuals, but the magnitude of the change for many individuals was not dramatic. Implications for child psychopharmacology research and differences between clinical and experimental significance are discussed.

References

Jul 6, 1978·Psychopharmacology·S M EastgateJ S Werry
Jan 1, 1979·Journal of Applied Behavior Analysis·C K WhalenS Dotemoto
Jan 1, 1975·Journal of Abnormal Child Psychology·J S WerryM N Cohen
Aug 1, 1973·Pediatric Clinics of North America·R L Sprague, E K Sleator
Mar 1, 1974·The Australian and New Zealand Journal of Psychiatry·J S Werry, R L Sprague

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Citations

Mar 1, 1986·Journal of Abnormal Child Psychology·B HenkerJ W Varni
Dec 1, 1981·Journal of Abnormal Child Psychology·C K WhalenD Finck
Mar 1, 1982·Australian Paediatric Journal·M Prior
Mar 1, 1985·Journal of Abnormal Child Psychology·L I Mintz, B E Collins
Jun 1, 1981·The Australian and New Zealand Journal of Psychiatry·M Prior
Aug 1, 1987·Psychological Reports·J B Murray
Aug 17, 2000·The British Journal of Psychiatry : the Journal of Mental Science·C EvenR M Dardennes
Jun 1, 1983·Developmental Medicine and Child Neurology·K J Ottenbacher, H M Cooper
Oct 1, 1983·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·M M Konstantareas, S Homatidis
Jun 13, 1980·Science·C K WhalenS Dotemoto

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