Double-blind clonazepam vs placebo in panic disorder treatment

Arquivos de neuro-psiquiatria
A M ValençaW Zin


To assess the effectiveness of clonazepam, in a fixed dose (2 mg/day), compared with placebo in the treatment of panic disorder patients. 24 panic disorder patients with agoraphobia were randomly selected. The diagnosis was obtained using the structured clinical interview for DSM-IV. All twenty-four subjects were randomly assigned to either treatment with clonazepam (2 mg/day) or placebo, during 6 weeks. Efficacy assessments included: change from baseline in the number of panic attacks; CGI scores for panic disorder; Hamilton rating scale for anxiety; and panic associated symptoms scale. At the therapeutic endpoint, only one of 9 placebo patients (11.1%) were free of panic attacks, compared with 8 of 13 (61.5%) clonazepam patients (Fisher exact test; p=0,031). the results provide evidence for the efficacy of clonazepam in panic disorder patients.


May 1, 1991·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·H PolsE Griez
Jan 1, 1991·Acta Psychiatrica Scandinavica·N ArgyleP Bech
Jun 1, 1987·Journal of Clinical Psychopharmacology·J B HermanA W Brotman
Aug 1, 1986·The Journal of Nervous and Mental Disease·G E Tesar, J F Rosenbaum
Apr 1, 1997·Archives of General Psychiatry·M M WeissmanE K Yeh
Aug 5, 1998·International Clinical Psychopharmacology·J C Ballenger

❮ Previous
Next ❯


May 21, 2008·The Psychiatric Quarterly·Rif S El-Mallakh, Michael Hollifield
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dietmar WinklerSiegfried Kasper
Jun 23, 2005·Current Medical Research and Opinion·Eric Michael Kaplan, Robert L DuPont
Feb 24, 2011·Expert Opinion on Pharmacotherapy·Rafael C FreireAntonio E Nardi
Apr 1, 2004·Acta Neuropsychiatrica·A C PyleD J Nutt
Jul 27, 2004·Arquivos de neuro-psiquiatria·Alexandre M ValençaMarcio Versiani
Mar 11, 2006·International Clinical Psychopharmacology·Antonio E Nardi, Giampaolo Perna
Dec 27, 2011·Journal of Clinical Psychopharmacology·Antonio E NardiMarcio Versiani
Mar 29, 2019·The Cochrane Database of Systematic Reviews·Johanna BreilmannMarkus Koesters
Jul 16, 2019·Journal of Psychopharmacology·Laiana A QuagliatoUNKNOWN International Task Force on Benzodiazepines
Jan 24, 2018·Expert Opinion on Drug Safety·Laiana A QuagliatoAntonio E Nardi
Feb 10, 2004·CNS Spectrums·Mark H PollackUNKNOWN World Council of Anxiety
Mar 3, 2011·Journal of Clinical Psychopharmacology·Antonio E NardiMarcio Versiani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.