PMID: 3760275Sep 1, 1986Paper

Double-blind comparison of 2% ketoconazole cream and placebo in the treatment of tinea versicolor

Journal of the American Academy of Dermatology
R C Savin, S N Horwitz

Abstract

Malassezia furfur (Pityrosporum orbiculare) was confirmed by microscopic potassium hydroxide (KOH) examination in 101 patients with recurring lesions of tinea versicolor. In a double-blind comparative study, patients were randomly assigned to once-daily ketoconazole 2% or placebo cream. At the end of treatment, 98% (p less than 0.0001) of the patients using ketoconazole and 28% of those using placebo responded clinically (healed or had mild residual disease). There was an overall 84% mycologic cure rate (negative KOH at treatment end) for patients using ketoconazole 2% cream and 10% for those using placebo cream (p less than 0.0001). Ketoconazole-treated patients who were cured at the end of treatment remained cured 8 weeks later. By contrast 75% of those responding to placebo had relapsed by the 8-week follow-up visit. Follow-up after 2 years revealed that 79% (38/48) of the patients treated with ketoconazole remained clear 12 or more months.

References

May 1, 1984·Journal of the American Academy of Dermatology·R C Savin

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Citations

Mar 5, 2013·Sports Medicine·Joshua A FarhadianMiguel R Sanchez
Jun 1, 1987·Journal of the American Academy of Dermatology·R J Coskey
Apr 1, 1988·Journal of the American Academy of Dermatology·D Greer, H W Jolly
Sep 6, 2003·Dermatologic Clinics·Aditya K GuptaJan Faergemann
Nov 13, 2001·American Journal of Clinical Dermatology·J Faergemann
May 1, 1994·Journal of the American Academy of Dermatology·A K GuptaN H Shear
Aug 19, 2005·Expert Review of Anti-infective Therapy·Adolfo C Fernandez-ObregonCarolyn Willis
Jan 23, 2019·The Journal of Dermatological Treatment·Franchesca D ChoiNatasha Atanaskova Mesinkovska
Mar 11, 2005·Expert Opinion on Pharmacotherapy·Aditya K GuptaRoma Batra
Dec 21, 2019·Dermatologic Therapy·Jaime R FieldsJennifer J Schoch
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Markus DoldStefan Leucht
Sep 27, 2020·The Journal of Dermatology·Takashi MochizukiUNKNOWN Guidelines Committee of the Japanese Dermatological Association
Apr 16, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaR Summerbell
Feb 3, 2004·The Journal of Dermatological Treatment·A K GuptaA Johnson
Mar 12, 2015·Journal of Fungi·Aditya K Gupta, Kelly A Foley

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