PMID: 7044045Apr 1, 1982

Double-blind comparison of doxepin and desipramine in patients with primary affective disorder

Acta Psychiatrica Scandinavica
J D AmsterdamK Rickels


A double-blind comparison of doxepin versus desipramine was performed in carefully defined patients with research diagnosis of Primary Affective Disorder. While both drugs showed equal efficacy after 4 weeks, doxepin demonstrated a more rapid onset of action and surprisingly few side effects. Desipramine did not prove to be "activating" and did not worsen agitated depression. Although doxepin showed few autonomic side effects, it was nevertheless sedating, indicating that tricyclics with more anticholinergic effects are not necessarily more sedating drugs.


Jan 1, 1976·The Journal of International Medical Research·O ElwanM A Hassan
Jun 1, 1978·Archives of General Psychiatry·R L SpitzerE Robins
Oct 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·G D BurrowsB Davies
May 1, 1974·Archives of General Psychiatry·J B Morris, A T Beck
Apr 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·J A Stewart, P H Mitchell
Oct 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·I Haider
Jan 1, 1980·Progress in Neuro-psychopharmacology·P D Hrdina, Y D Lapierre
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON


Jan 1, 1983·Psychopharmacology·J D AmsterdamK Rickels
Dec 1, 1981·Journal of Affective Disorders·J D AmsterdamP Snyder
Mar 12, 1998·Journal of Affective Disorders·H Müller, H J Möller
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·G W VogelA Hennessey

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