Double-blind comparison of epidural ropivacaine 0.25% and bupivacaine 0.25%, for the relief of childbirth pain

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
H MuirA Macarthur

Abstract

To evaluate the efficacy of ropivacaine 0.25% when administered epidurally for relief of labour pain and to compare it with bupivacaine 0.25%. In a multicentre investigation, 60 ASA I and II labouring women were randomized in a double-blind fashion to receive either bupivacaine 0.25% or ropivacaine 0.25% administered epidurally by intermittent top-up for labour analgesia. Using a standardized technique, epidural analgesia was initiated after the woman received 10-15 ml-kg.1 crystalloid solution. Maternal blood pressure, heart rate, analgesia sensory level, degree of motor block and visual analogue pain scores were measured by the research nurse prior to, and at regular intervals, following the administration of analgesia. Total dose of local anaesthetic administered, duration of labour, mode of delivery, and maternal and fetal/neonatal side effects were noted. The fetus/neonate was assessed by the research nurse using the fetal heart rate tracing, Apgar scores at delivery and neonatal neurobehavioural assessments at 2 and 24 hr postnatally. Maternal and investigators' satisfaction with the analgesia achieved was assessed after delivery. No differences were found between the two agents in any of the variables studied. Ropivacain...Continue Reading

References

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Citations

Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas StandlJochen Schulte Am Esch
Feb 9, 2000·Pharmacology & Therapeutics·N J O'Keeffe, T E Healy
Oct 17, 1998·Acta Anaesthesiologica Scandinavica·S Alahuhta, T I Ala-Kokko
Apr 12, 2005·Drugs·Chester C Buckenmaier, Lisa L Bleckner
Feb 19, 1999·Baillière's Clinical Obstetrics and Gynaecology·E M YunA C Santos
May 15, 2002·Seminars in Perinatology·Scott M Drysdale, Holly Muir
Apr 18, 2003·Anesthesiology Clinics of North America·Moeen Panni, Scott Segal
Jun 5, 2001·Anesthesiology·B B LeeJ Y Liu
Nov 7, 1999·Anesthesiology·S KhalilA Chuang
Apr 23, 2003·Anesthesia and Analgesia·Stephen H Halpern, Vivien Walsh
Nov 24, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Wolfgang Zink, Bernhard M Graf
Jul 22, 2005·Legal Studies : the Journal of the Society of Legal Scholars·Sabine Michalowski
Sep 28, 2005·Legal Studies : the Journal of the Society of Public Teachers of Law·D Price
Jun 21, 2002·European Journal of Anaesthesiology·G Capogna
Oct 3, 2006·Current Opinion in Anaesthesiology·L E Mather, S R Edwards
Oct 3, 2006·Current Opinion in Anaesthesiology·G O'Sullivan
Oct 3, 2006·Current Opinion in Anaesthesiology·H A Muir
Apr 10, 2002·Acta Anaesthesiologica Scandinavica·K Hofmann-KieferD Schwender
Jul 16, 2019·Journal of Anaesthesiology, Clinical Pharmacology· Hemlata

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