Jan 1, 1979

Double-blind comparison of metoprolol, alprenolol, and oxprenolol in hypertension

European Journal of Clinical Pharmacology
J Tuomilehto, A Nissinen


A double-blind comparison of the beta-blockers metoprolol, alprenolol and oxprenolol was carried out to evaluate their antihypertensive effect and tolerability. 105 patients with previously untreated hypertension entered the trial and 72 completed it. Side-effects were infrequent and were never the reason for drop-out. All three drugs caused a statistically significant reduction in blood-pressure at the lower of the two doses used during a dose-finding period. At the higher dose employed in this period, metoprolol caused a significantly greater reduction in diastolic blood-pressure than did alprenolol or oxprenolol. All three drugs caused a significant reduction in heart rate. During the following period, the beta-blockers were supplemented if necessary with hydrochlorothiazide. This was required less frequently in the metoprolol group than in the other two groups.

Mentioned in this Paper

Diastolic Blood Pressure
Hypertensive Disease
Antihypertensive Agents
In Blood
Clinical Trials

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