Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin

The New England Journal of Medicine
C R SmithP S Lietman

Abstract

Two hundred fifty-eight patients with suspected sepsis were treated with tobramycin or gentamicin in a prospective, randomized, double-blind trial. One hundred forty-six patients received nine or more doses, had serial determinations of serum creatinine, and were evaluated for nephrotoxicity; 91 were able to cooperate with audiometry and were evaluated for auditory toxicity. Auditory toxicity developed in five of 47 (10 per cent) given gentamicin and five of 44 (11 per cent) given tobramycin. Nephrotoxicity developed in 19 of 72 (26 per cent) given gentamicin and nine of 74 (12 per cent) given tobramycin (P less than 0.025). The severity of the nephrotoxicity was not different; the mean increase in creatinine was 1.3 mg per 100 ml (114.9 mumol per liter) in both groups. Both the tobramycin and gentamicin groups had a similar mean age, initial serum creatinine level, total dose, serum aminoglycoside level, and duration of therapy. We conclude that tobramycin causes nephrotoxicity less frequently than does gentamicin.

References

May 1, 1978·The Journal of Antimicrobial Chemotherapy·M Akiyoshi
Feb 17, 1977·The New England Journal of Medicine·C R SmithP S Lietman
Jun 1, 1979·Antimicrobial Agents and Chemotherapy·C R SmithP S Lietman
Jan 1, 1978·Antimicrobial Agents and Chemotherapy·D N GilbertG Porter
May 1, 1978·The Journal of Antimicrobial Chemotherapy·W E FeeG R Lathrop
May 1, 1978·The Journal of Antimicrobial Chemotherapy·G KahlmeterC Kamme
May 1, 1978·The Journal of Antimicrobial Chemotherapy·M BarzaT Murray
May 1, 1978·The Journal of Antimicrobial Chemotherapy·R E BrummettD L Himes
Aug 1, 1976·The Journal of Infectious Diseases·P O MadsenA Mosegaard
Mar 16, 1972·The New England Journal of Medicine·D H SmithA L Smith
Feb 1, 1974·Antimicrobial Agents and Chemotherapy·J KlasterskyD Daneau
May 1, 1972·Annals of Internal Medicine·R A ChanP D Hoeprich
Feb 13, 1969·The New England Journal of Medicine·R H Gifford, A R Feinstein

Citations

Jul 1, 1993·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J H JoshiS C Schimpff
Mar 1, 1992·Indian Pediatrics·G R SinghR K Puri
Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N GordjaniM Brandis
Apr 12, 1995·Molecular and Cellular Biochemistry·P SandhyaP Varalakshmi
Jan 1, 1988·International Urology and Nephrology·L LöcseyG Kakuk
Jan 1, 1986·Indian Journal of Pediatrics·D A MacKintosh
Sep 1, 1981·Indian Journal of Pediatrics·A Kumar
Nov 14, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Detlef BockenhauerRobert Kleta
Mar 15, 2006·Digestive Diseases and Sciences·Zvi AckermanOrit Pappo
Mar 27, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·T B VreeB Jongman-Nix
Jun 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M WernerR Nayar
Feb 1, 1995·Journal of Hepatology·M I LucenaF Sanchez de la Cuesta
Mar 1, 1989·Toxicology Letters·G D NuytsM E De Broe
Mar 1, 1989·Toxicology Letters·P Tulkens
Aug 1, 1990·Toxicology Letters·P J GovaertsM E De Broe
Mar 1, 1995·Journal of Critical Care·R Hock, R J Anderson
Sep 5, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Brian G KeevilDonald P Cooper
Oct 7, 1993·The New England Journal of Medicine·J B Nadol
Oct 13, 2009·QJM : Monthly Journal of the Association of Physicians·Nicholas M SelbyNitin V Kolhe
Apr 11, 2008·Critical Care Medicine·Neesh Pannu, Mitra K Nadim
Apr 11, 2007·Current Opinion in Nephrology and Hypertension·Sushrut S WaikarGlenn M Chertow
Jun 1, 1995·British Journal of Clinical Pharmacology·E J BeggS B Duffull
Feb 1, 1994·Clinical and Experimental Pharmacology & Physiology·H O GarlandE S Harpur
May 1, 1981·Antimicrobial Agents and Chemotherapy·J J SchentagF B Cerra
Dec 1, 1981·Antimicrobial Agents and Chemotherapy·D J EdwardsJ J Schentag
Mar 1, 1982·Antimicrobial Agents and Chemotherapy·D E ZaskeR G Strate
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·A E BrownD Armstrong
May 1, 1982·Antimicrobial Agents and Chemotherapy·J J SchentagM E Plaut
Nov 1, 1982·Antimicrobial Agents and Chemotherapy·M AdelmanJ J Schentag
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·C R Smith, P S Lietman
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·B F Farber, R C Moellering
Oct 1, 1983·Antimicrobial Agents and Chemotherapy·R G PennD K Giger
Oct 1, 1983·Antimicrobial Agents and Chemotherapy·G LaurentP Tulkens
Nov 1, 1984·Antimicrobial Agents and Chemotherapy·J M GatellM T Jimenez de Anta
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·R F AmbinderP S Lietman
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·A ContrepoisC Carbon
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·S T Donta, L A Lembke
Apr 1, 1987·Antimicrobial Agents and Chemotherapy·S S PedersenP Osterhammel
Aug 1, 1988·Antimicrobial Agents and Chemotherapy·M G BergeronN B Segal
Nov 1, 1989·Antimicrobial Agents and Chemotherapy·T M BiancoJoseph S Bertino
Jun 1, 1989·Antimicrobial Agents and Chemotherapy·R E Brummett, K E Fox
Jun 1, 1989·Antimicrobial Agents and Chemotherapy·A M ContrerasA Espinosa
May 1, 1990·Antimicrobial Agents and Chemotherapy·P AuclairM G Bergeron
Nov 1, 1984·The British Journal of Ophthalmology·N H WelshS L Gaffin
Sep 1, 1981·Postgraduate Medical Journal·M Fiala, S N Chatterjee
Oct 1, 1980·The Laryngoscope·W E Fee
Nov 1, 1989·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A TamirE Bogin
Jan 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J SatlinThomas J Walsh
May 30, 2014·The Journal of Antimicrobial Chemotherapy·Erik van MaarseveenDaniel Touw
Aug 15, 1985·American Journal of Ophthalmology·D J D'AmicoK R Kenyon
Oct 11, 2014·BMC Infectious Diseases·Chawangwa ModongoNicola M Zetola
Jan 1, 1982·Infection·A PinesO Frankl
Dec 29, 2012·Scandinavian Journal of Infectious Diseases·Håkan HanbergerSwedish Reference Group for Antibiotics
May 1, 1982·British Journal of Audiology·P Noone
Jan 1, 1988·Critical Reviews in Toxicology·G LaurentP Maldague
Jan 1, 1982·Current Medical Research and Opinion·A M AbbasM M Zaman
Jan 1, 1984·Issues in Comprehensive Pediatric Nursing·J H Boffman
Jan 1, 1989·Medical Toxicology and Adverse Drug Experience·G Koren
Sep 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R A Zager
Nov 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C R SmithP S Lietman
Apr 1, 1984·Kidney International·M E De BroeP Tulkens
Jan 1, 1983·Kidney International·S I Vas
Feb 1, 1981·Kidney International·N SchorB M Brenner
May 1, 1999·Antimicrobial Agents and Chemotherapy·M P Mingeot-Leclercq, P Tulkens
May 13, 1999·Mayo Clinic Proceedings·R S Edson, C L Terrell
Mar 26, 2008·Critical Care Clinics·Eric V Granowitz, Richard B Brown
Aug 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·R L Wynn
Jul 1, 1986·Toxicology and Applied Pharmacology·A BernardR Lauwerys
Jul 28, 2004·Chemico-biological Interactions·Chie YanagidaToshiharu Horie
Jul 1, 1987·The Journal of Hospital Infection·A WebsterR N Grüneberg
Feb 1, 1983·The American Journal of Medicine·S H HouJ T Harrington
Sep 1, 1987·Survey of Ophthalmology·K R WilhelmusM S Osato
Jun 30, 1986·The American Journal of Medicine·D A EvansC Hennekens
Oct 1, 1984·The American Journal of Medicine·R D MooreP S Lietman
Nov 15, 2014·British Journal of Clinical Pharmacology·Lauren N FaughtKoren Gideon
Mar 12, 2016·Journal of Medicinal Chemistry·Bo WangPatrick M Woster
Dec 1, 1987·Journal of Clinical Pharmacy and Therapeutics·G R Bailie, A Mathews
Oct 1, 1987·Journal of Clinical Pharmacy and Therapeutics·A Mathews, G R Bailie
Aug 1, 1985·Australian and New Zealand Journal of Medicine·N Buchanan
Mar 1, 1985·Journal of Clinical Pharmacology·A Whelton
Oct 1, 1983·Journal of Clinical Pharmacology·A Whelton, K Solez
Jul 1, 1983·The Journal of Pediatrics·M C NahataJ P Glazer
Aug 1, 1995·Journal of Chemotherapy·G Gialdroni Grassi
Aug 1, 1995·Journal of Chemotherapy·P Periti
Oct 14, 1998·Pathology·D L PatersonM Peters
Jul 11, 2015·Journal of Cellular and Molecular Medicine·Kun GaoJian Yao
Feb 8, 1985·The American Journal of Medicine·J G PastorekJ C Crapanzano
Mar 15, 2015·The Journal of Antimicrobial Chemotherapy·Pyry A J ValitaloCatherijne A J Knibbe
Dec 3, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lingyun ChenMei Shen
Aug 6, 2016·The Journal of Antimicrobial Chemotherapy·Lizhen OngHorng-Ruey Chua
Aug 31, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Matthew E FalagasArgyris Michalopoulos
Aug 1, 1982·Toxicology and Applied Pharmacology·A L SvecT R Meyers
Apr 5, 2017·BMC Nephrology·Linda Awdishu, Ravindra L Mehta
Oct 1, 1986·Journal of Biomaterials Applications·M SzycherG Battistone
Jan 1, 1989·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J G Dolan
Jan 8, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Christopher P Scott, Paul A Higham
Jan 1, 1986·Journal of Ocular Pharmacology·I H Leopold
Jan 1, 1989·Pediatric Pulmonology·G SteinkampH von der Hardt
Jul 1, 1997·Clinical Pharmacology and Therapeutics·J M PrinsP Speelman
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S Lietman
Apr 1, 1984·International Journal of Dermatology·R H Eng
Feb 1, 1982·Australian and New Zealand Journal of Medicine·C W Clarke, G E Marlin
Jun 1, 1993·Journal of Clinical Pharmacy and Therapeutics·D Bertram, R Summers
Jul 25, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Joseph A PaladinoJ J Schentag
Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sushrut S WaikarGlenn M Chertow
Apr 1, 1981·Annals of Neurology·W E Bell
Jun 1, 1996·Therapeutic Drug Monitoring·D P NicolauC H Nightingale
Jan 1, 1983·Drug Intelligence & Clinical Pharmacy·J S Kaka, E C Buchanan
Jan 1, 1986·Toxicologic Pathology·G H Hottendorf
Jun 1, 1990·The Annals of Otology, Rhinology & Laryngology. Supplement·G J Matz
Apr 1, 1981·Drug Intelligence & Clinical Pharmacy·J C MannionN G Popovich
Jan 1, 1980·Scandinavian Journal of Infectious Diseases. Supplementum
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·G J GorseP S Etzell
Dec 1, 1982·Drug Intelligence & Clinical Pharmacy·D A Apgar
Jan 1, 1988·Pharmacotherapy·B A Cunha
Apr 1, 1985·Postgraduate Medicine·J T Johnson, D B Kamerer
Nov 1, 1989·Medical Toxicology and Adverse Drug Experience·M Y Huang, J Schacht
Aug 1, 1991·Postgraduate Medicine·E Farrugia, T S Larson
Sep 19, 1998·International Journal of Experimental Pathology·M ChengT Taguchi
Aug 29, 2018·Nature Communications·Zohar B WeinsteinMurat Cokol
Nov 1, 1981·Drug Intelligence & Clinical Pharmacy·W S Burkle
Feb 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J Satlin
Jun 1, 1984·Infection Control : IC·R J Geller, S M Norris
Jan 1, 1984·The Laryngoscope·J T JohnsonV L Schramm
Nov 5, 1990·The Medical Journal of Australia·L B Jellett, V J Heazlewood
Sep 1, 1986·The Medical Journal of Australia·P Rolan, A Somogyi
Oct 1, 1984·Orthopedics·G H Karam

Related Concepts

Antibiotics
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Krebiozen
Double-Blind Method
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Kidney
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