PMID: 4904935Jan 24, 1970Paper

Double-blind controlled clinical trial of clofazimine in reactive phases of lepromatous leprosy

British Medical Journal
A B KaratP S Rao

Abstract

A double-blind controlled trial in 24 lepromatous leprosy patients in reaction showed that clofazimine (Lamprene) controlled symptoms of erythema nodosum leprosum reaction in lepromatous leprosy better than prednisolone. Clofazimine also appeared to be significantly superior in preventing recurrence once the reaction had been controlled. There was a statistically significant rise in serum albumin among inpatients on clofazimine as compared with patients on prednisolone, but no difference in terms of neurological status, bacterial index, morphological index, and renal functions. Red/black hyperpigmentation was seen among practically all patients on clofazimine. No other side-effects or deleterious systemic effects were observed.

Citations

Apr 1, 1972·The Australasian Journal of Dermatology·R B Smith
Jan 1, 1995·Drug Metabolism Reviews·R O'ConnorR O'Kennedy
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Natasja H J Van VeenJan Hendrik Richardus
Dec 9, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xinxin FengEric Oldfield
Apr 3, 2016·The Lancet Infectious Diseases·Robert S WallisAlimuddin Zumla
May 1, 1986·Antimicrobial Agents and Chemotherapy·V AusinaG Prats

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