Double-blind evaluation of the efficacy and safety of temazepam in outpatients with insomnia

British Journal of Clinical Pharmacology
J M Fillingim

Abstract

1 The efficacy and safety of temazepam 30 mg, compared with glutethimide 500 mg and placebo, were evaluated in double-blind conditions in a 4-day study in 75 outpatients with a history of insomnia. 2 Temazepam and glutethimide were rated by the patients as effective and significantly superior to placebo for general quality of sleep, time required to fall asleep, frequency of nocturnal and early morning awakenings, and duration of sleep. 3 Residual effects reported for temazepam and glutethimide immediately after awakening and during the day were similar to or less than those reported for placebo.

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·F O MüllerG C Dunbar
Jan 1, 1984·Current Medical Research and Opinion·R BanderaS Garattini
Nov 5, 2013·Drug Discovery Today·Weng Ieong Tou, Calvin Yu-Chian Chen
Jun 1, 1984·British Journal of Clinical Pharmacology·T RoehrsT Roth
Mar 7, 2006·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Russell P Rosenberg
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Andrew D KrystalLiza H Ashbrook
Jul 1, 1981·Pharmacotherapy·M M Mitler
Sep 1, 1982·Drug Intelligence & Clinical Pharmacy·J C McElnayB Alexander
Jan 1, 1981·British Journal of Clinical Pharmacology·A N Nicholson

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