PMID: 15218410Jun 26, 2004Paper

Double-blind parallel comparison of multiple doses of apraclonidine, clonidine, and placebo administered intra-articularly to patients undergoing arthroscopic knee surgery

The Clinical Journal of Pain
Ping-Heng TanLin-Cheng Yang

Abstract

This clinical study assessed and compared the potential analgesic and adverse effect of IA apraclonidine with IA clonidine. Eighty patients scheduled for arthroscopic knee surgery under general anesthesia were randomized to receive, in a double-blind manner, either IA normal saline (group 1), 50 microg IA apraclonidine (group 2), 150 microg IA apraclonidine (group 3), or 150 microg IA clonidine (group 4), all in a volume of 20 mL subsequent to surgery. Visual analog pain scores (VAS), the duration of analgesia as defined by the time to first demand for supplemental analgesics, the subsequent 24-hour consumption of postoperative supplementary analgesics, and patient adverse effects were evaluated. The patients from groups 3 and 4 demonstrated a longer duration of analgesia and used fewer analgesics in the first postoperative 24 hour period compared with group 1 and 2 patients (P < 0.05). The VAS scores corresponding to the periods 1, 2, and 4 hours postoperatively were significantly lower for group 3 than for group 1 patients. The VAS scores at 1 and 4 hours postoperatively were also lower for group 3 than for group 2 patients (P < 0.05). There was no significant difference in the incidence of side effects among the 4 groups. Th...Continue Reading

References

May 1, 1992·Anesthesia and Analgesia·D M GaumannP Jirounek
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Sep 15, 1990·American Journal of Ophthalmology·M H King, D W Richards
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Jan 29, 2000·Anesthesia and Analgesia·B Ong

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Citations

Jul 21, 2004·Journal of Endourology
Jun 24, 2008·British Journal of Anaesthesia·R R Al-MetwalliA-R El-Saleh
Jul 25, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Rao SunKehu Yang
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Alexander Valverde
Dec 30, 2015·Anesthesia, Essays and Researches·Riddhi KunduH L Nag
Jan 3, 2021·Research in Veterinary Science·Alessandra Di SalvoGiorgia Della Rocca

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