PMID: 6987988Feb 1, 1980Paper

Double-blind placebo controlled crossover evaluation of levamisole in rheumatoid arthritis

Arthritis and Rheumatism
B MillerH E Paulus

Abstract

During levamisole therapy, 14 of 20 patients with previously unresponsive rheumatoid arthritis had significant improvement (P less than 0.05) in clinical measures of disease activity, erythrocyte sedimentation rate, and rheumatoid factor titer in a 32-week double-blind placebo controlled crossover trial. Levamisole was shown to alter antibody responses to tetanus and typhoid antigens, lymphocyte blastogenesis to phytohemagglutinins, and the number of null cells in peripheral blood. Agranulocytosis and rash resulted in discontinuation of the drug in one patient in each group. Though clearly effective, routine use of levamisole as a disease suppressant in rheumatoid arthritis must await more complete clarification of its association with agranulocytosis.

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Citations

Dec 1, 1986·Immunopharmacology·K KobayashiY Shiokawa
Jul 29, 1982·The New England Journal of Medicine·H DonabedianJ I Gallin
Dec 1, 1980·Arthritis and Rheumatism·E M Veys, H Mielants
Oct 10, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Rabia RazaJamshed Iqbal
Sep 29, 2009·Bioorganic & Medicinal Chemistry·Lina LiYuqing Wu

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