Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography

Human Psychopharmacology
Peter AndererGerda Saletu-Zyhlarz

Abstract

Early pharmacological studies in animals demonstrated that ABIO-08/01, a new isoxazoline, exerted anxiolytic and anticonvulsant, but also cognition-enhancing properties. Thus, the aim of the present double-blind, placebo-controlled multiple-ascending-dose study was to investigate the effect of the new compound on event-related potentials (ERPs). In a randomized ascending-dose design for phase-1 studies, 16 young healthy male subjects aged 30.2 +/- 5.7 years received three ascending drug doses (10, 20, and 40 mg) and placebo for 7 days, with a washout period of 8 days in between. Auditory ERPs were recorded pre-dose and 2 h post-dose on days 1 (acute effect) and 5 (subacute and absolute superimposed effect). Descriptive statistics with one confirmatory statement on P300 latency demonstrated a significant shortening after acute, subacute, and superimposed administration of 40 mg ABIO-08/01. While ERP amplitudes showed only minor effects, low-resolution brain electromagnetic tomography (LORETA) demonstrated that ABIO-08/01 promotes more efficient information processing by reallocating perceptual and cognitive ERP resources. Thus, our ERP studies confirm early pharmacological findings in animals of a cognition-enhancing effect of A...Continue Reading

References

Apr 1, 1975·Electroencephalography and Clinical Neurophysiology·N K SquiresS A Hillyard
Jan 1, 1977·Neuropsychobiology·B Saletu
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·M M LoristA Kok
Oct 1, 1994·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R D Pascual-MarquiD Lehmann
Mar 21, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J Polich
Aug 26, 1998·Electroencephalography and Clinical Neurophysiology·W K StrikR D Pascual-Marqui
Sep 19, 1998·Electroencephalography and Clinical Neurophysiology·E HalgrenP Chauvel
Sep 8, 2001·Brain Topography·G WintererW M Herrmann
Feb 26, 2003·Neurobiology of Aging·P AndererR D Pascual-Marqui

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Citations

Dec 30, 2014·Expert Opinion on Investigational Drugs·Giampaolo PernaDaniela Caldirola
Aug 23, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Claudio BabiloniGiuseppe Cibelli
Aug 4, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ki-Young JungSeung Bong Hong
May 26, 2009·Arquivos brasileiros de endocrinologia e metabologia·Yu WangAimin Xu
Jun 5, 2015·Medical & Biological Engineering & Computing·Joan Francesc AlonsoManel José Barbanoj

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