Double-blind, placebo-controlled, randomized study comparing 0.0003% calcitriol with 0.1% tacrolimus ointments for the treatment of endemic pityriasis alba.

Dermatology Research and Practice
Berenice Moreno-CruzJuan Pablo Castanedo-Cazares

Abstract

Background. Pityriasis alba (PA) is a frequent cause of consultation in tropical areas due to its chronic course, frequent relapses, and notorious hypopigmented lesions in pediatric dark skin populations. Currently, no treatment is widely accepted. Objective. To assess the efficacy of 0.0003% calcitriol and 0.1% tacrolimus ointments compared with placebo in the treatment of endemic PA. Methods. Twenty-eight children aged 3-17 years with 56 symmetrical lesions and phototype IV-V, were randomly assigned to receive the treatments on target lesions on the face. Improvement was evaluated at baseline and 8 weeks later clinically and by digital quantification of the affected area, colorimetry, and transepidermal water loss (TEWL). Results. Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL. Conclusions. Calcitriol and tacrolimus induced similar repigmentation in endemic PA lesions. Melanogenic, anti-inflammatory, and barrier defect restoration properties of these drugs may explain these findings.

References

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Citations

Dec 3, 2014·Clinics in Dermatology·Kabir Sardana
Feb 24, 2015·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Paula BarbelKathleen Peterson
Oct 20, 2015·Pediatric Dermatology·Nina MiazekLidia Rudnicka
Oct 24, 2012·Journal of Skin Cancer·Gérald E Piérard, Claudine Piérard-Franchimont
Oct 22, 2019·International Journal of Clinical Practice·Abdurakhim ToychievSvetlana Osipova
Aug 13, 2020·International Journal of Dermatology·Laura D ChinRichard M Haber
Mar 19, 2014·Journal of Cutaneous Medicine and Surgery·Heidi Wat, Marlene Dytoc
Jul 29, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Leah CohenRichard F Lockey
Jul 23, 2021·The Journal of Dermatological Treatment·Hossam M Abdel-Wahab, Maha H Ragaie

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Clinical Trials Mentioned

NCT01388517

Software Mentioned

JMP
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