Double-blind placebo-controlled randomized clinical trial of ginger ( Zingiber officinale Rosc.) addition in migraine acute treatment

Cephalalgia : an International Journal of Headache
Laís Bhering MartinsAdaliene Versiani Matos Ferreira

Abstract

Previous studies have demonstrated the analgesic effects of ginger in different conditions, but evidence about its efficacy in migraine treatment is scarce. This study aimed to evaluate the potential of ginger to improve acute migraine as an add-on strategy to standard treatment. A double-blind placebo-controlled randomized clinical trial in the emergency room of a general hospital was conducted. Patients who sought medical care at the time of migraine attack were enrolled in this study. Only adults with episodic migraine (one to six migraine attacks per month) with or without aura were included. Sixty participants were randomized into two groups in which they received 400 mg of ginger extract (5% active ingredient) or placebo (cellulose), in addition to an intravenous drug (100 mg of ketoprofen) to treat the migraine attack. Patients filled a headache diary before, 0.5 h, 1 h, 1.5 h and 2 h after the medication. Pain severity, functional status, migraine symptoms and treatment satisfaction were also recorded. Patients treated with ginger showed significantly better clinical response after 1 h ( p = 0.04), 1.5 h ( p = 0.01) and 2 h ( p = 0.04). Furthermore, ginger treatment promoted reduction in pain and improvement on function...Continue Reading

Associated Clinical Trials

Oct 6, 2015·Antonio L Teixeira JrAntonio L Teixeira Jr

References

Dec 1, 1992·Medical Hypotheses·K C Srivastava, T Mustafa
Feb 1, 1992·Chemical & Pharmaceutical Bulletin·F KiuchiU Sankawa
Jul 1, 1990·Journal of Ethnopharmacology·T Mustafa, K C Srivastava
Jan 25, 2002·The New England Journal of Medicine·Peter J GoadsbyMichel D Ferrari
Nov 2, 2002·British Journal of Pharmacology·Vadim N DedovBasil D Roufogalis
Nov 19, 2002·São Paulo Medical Journal = Revista Paulista De Medicina·Yara Dadalti Fragoso
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Dec 4, 2003·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M KosinskiS Tepper
Mar 23, 2004·Langenbeck's Archives of Surgery·Hans-Georg Schaible, Frank Richter
May 25, 2005·Neurology·Christian Waeber, Michael A Moskowitz
Aug 25, 2005·Journal of Medicinal Food·Reinhard GrzannaCarmelita G Frondoza
Oct 1, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S ChrubasikB D Roufogalis
Jan 31, 2007·Neurology·R B LiptonUNKNOWN AMPP Advisory Group
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Suzanna M ZickDean E Brenner
Jan 24, 2009·International Journal of Sport Nutrition and Exercise Metabolism·Christopher D Black, Patrick J Oconnor
Feb 17, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Giti OzgoliFariborz Moattar
Apr 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Christopher D BlackPatrick J O'Connor
Mar 1, 2011·Headache·Christina Sun-Edelstein, Alexander Mauskop
Mar 3, 2012·Cephalalgia : an International Journal of Headache·Peer Tfelt-HansenUNKNOWN International Headache Society Clinical Trials Subcommittee
Jul 12, 2012·BMC Complementary and Alternative Medicine·Parvin RahnamaMohsen Naseri
May 10, 2013·Phytotherapy Research : PTR·Mehdi MaghbooliMehran Yousefi
Oct 1, 2013·Disease-a-month : DM·Mary Beth BabosChristy McGhee

❮ Previous
Next ❯

Citations

Feb 23, 2019·Current Pain and Headache Reports·Rebecca Erwin WellsLaura Granetzke
Aug 11, 2019·Cephalalgia : an International Journal of Headache·Laís Bhering MartinsAdaliene Versiani Matos Ferreira
Feb 15, 2020·Cephalalgia : an International Journal of Headache·Alicia AlpuentePatricia Pozo-Rosich
Jun 12, 2019·Pediatric Annals·Anna E Esparham, Jennifer J Dilts
Dec 15, 2020·The American Journal of Chinese Medicine·Yanleng HuangLan Shen
Mar 7, 2021·Pharmaceutics·Behdad JahromiNebojsa Nick Knezevic
Dec 10, 2020·The American Journal of Emergency Medicine·Liyan Chen, Zhiyou Cai
Nov 15, 2020·Australasian Emergency Care·Alixandra WongJames A Hughes

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02568644

Software Mentioned

Matlab Mathworks
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Ethnopharmacology
T Mustafa, K C Srivastava
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
K L Grant, R B Lutz
Midwives
Denise Tiran
© 2022 Meta ULC. All rights reserved