PMID: 11910270Mar 23, 2002Paper

Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder

Journal of Clinical Psychopharmacology
E H TurnerNorman E Rosenthal

Abstract

A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the opposite effect. They decided to follow up on this finding with this formal study. The study followed a double-blind, randomized cross-over design. Sixteen untreated, depressed patients with SAD received single oral doses of metergoline 8 mg and of placebo, spaced 1 week apart. Fourteen patients were restudied after 2 weeks of light treatment. Depression ratings using the Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version were performed at baseline and at 3 and 6 days after each intervention. These data were analyzed by baseline-corrected repeated measures with analysis of variance. In the off-lights condition, severity of depression was diminished after metergoline compared with placebo administration (p = 0.001). Patient daily self-ratings suggested that the peak effect occurred 2 to 4 days after study drug administration. In contrast, after 2 weeks of treatment wi...Continue Reading

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Citations

Nov 8, 2005·Biological Psychiatry·Jack G ModellDonna S Wightman
Jun 3, 2016·Biological & Pharmaceutical Bulletin·Hye Duck Yeom, Jun-Ho Lee
Jul 27, 2018·Expert Opinion on Pharmacotherapy·Olivia CoolsBernard Sabbe
Jul 13, 2006·Expert Review of Neurotherapeutics·Dietmar WinklerSiegfried Kasper
Jul 26, 2005·CNS Spectrums·Edda PjrekSiegfried Kasper
Apr 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Apoorva M KulkarniKeun Woo Lee

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