Double-blind, placebo-controlled trial of famotidine in children with abdominal pain and dyspepsia: global and quantitative assessment

Digestive Diseases and Sciences
M C SeeK J Benkov

Abstract

To determine the benefit of using an H2-receptor antagonist in children with abdominal pain and dyspepsia, 25 such children were enrolled in a double-blind, placebo-controlled trial of famotidine. Global and quantitative pain assessments were done before and after each treatment period. The quantitative assessment was calculated based on the abdominal pain score that was the sum of three components. Based on the global evaluation, there was a clear benefit of famotidine over placebo (68% vs 12%). Using the quantitative assessment, however, the mean improvement of the score using famotidine versus placebo was not statistically significant (3.37+/-3.53 vs 1.66+/-2.7). There was a significant improvement in this score during the first treatment period regardless of medication used (period effect: P = 0.05). A subset of patients with peptic symptoms demonstrated a significant drug effect that outweighed the period effect (drug effect: P = 0.01; period effect: P = 0.02). We conclude that famotidine subjectively improves the symptoms of children with recurrent abdominal pain but not objectively using the derived score. However, famotidine is significantly more effective than placebo among children with peptic symptoms. The use of thi...Continue Reading

Citations

Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Craig A FriesenSusan M Abdel-Rahman
Mar 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Carlo Di LorenzoUNKNOWN NASPGHAN Committee on Chronic Abdominal Pain
Oct 29, 2005·Journal of Pediatric Gastroenterology and Nutrition·John V Campo
Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I HoffmanJ Tack
Sep 1, 2009·World Journal of Pediatrics : WJP·Rana Fayez AmmouryJoseph Marino Croffie
Dec 16, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Yuko IshizakiUNKNOWN Japanese Society of Psychosomatic Pediatrics
Sep 9, 2015·Journal of Pediatric Gastroenterology and Nutrition·Amara Nassar-Sheikh RashidMerit M Tabbers
Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Craig A FriesenSusan M Abdel-Rahman
Jun 3, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D K PrusatorB Greenwood-Van Meerveld
Feb 23, 2018·Journal of Pediatric Gastroenterology and Nutrition·Rebecca A AbbottStuart Logan
Mar 6, 2004·Pediatric Annals·Colin D Rudolph, Adrian Miranda
Jun 10, 2010·Expert Review of Gastroenterology & Hepatology·Eric Chiou, Samuel Nurko
Feb 18, 2014·The Cochrane Database of Systematic Reviews·Angela A Huertas-CeballosAlice E Martin
Jun 5, 2014·Journal of Pediatric Gastroenterology and Nutrition·Juliette M T M RuttenArine M Vlieger
Apr 16, 2016·Current Gastroenterology Reports·John V Lavigne, Miguel Saps
Mar 3, 2018·Paediatric Drugs·Andrea BrusaferroSusanna Esposito
Jun 9, 2018·World Journal of Gastroenterology : WJG·Niranga Manjuri Devanarayana, Shaman Rajindrajith
May 30, 2020·Journal of Paediatrics and Child Health·Scott Nightingale, Ajay Sharma
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Alyssa A Lebel
Jul 20, 2010·Journal of Pediatric Gastroenterology and Nutrition·G GuarisoP Facchin
Feb 18, 2014·The Cochrane Database of Systematic Reviews·Angela A Huertas-CeballosColin Macarthur
Sep 20, 2011·The American Journal of Clinical Hypnosis·David Gottsegen
Feb 11, 2015·Nature Reviews. Gastroenterology & Hepatology·Judith KorterinkMarc A Benninga
Mar 7, 2017·The Cochrane Database of Systematic Reviews·Alice E MartinStuart Logan
Apr 24, 2015·Journal of Pediatric Gastroenterology and Nutrition·Miguel SapsDamian Rzeznikiewiz
Mar 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Miguel Saps, Carlo Di Lorenzo
Apr 23, 2016·Indian Journal of Pediatrics·Manu R Sood, Sravan Reddy Matta
Jul 21, 2016·Journal of Pediatric Gastroenterology and Nutrition·Claudio RomanoMarc A Benninga
Feb 7, 2018·Expert Review of Gastroenterology & Hepatology·Shaman RajindrajithMarc A Benninga
Nov 17, 2007·Journal of Gastroenterology and Hepatology·Ahmad GhanizadehSeyed Mohsen Dehghani
Apr 2, 2008·Current Gastroenterology Reports·Maria E Perez, Nader N Youssef
Nov 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Amaranath KarunanayakeShaman Rajindrajith
Sep 1, 2006·Current Treatment Options in Gastroenterology·Adrian Miranda, Manu Sood
Oct 27, 2018·Expert Review of Clinical Pharmacology·Pamela D BrowneMerit M Tabbers
Mar 11, 2020·Archives of Disease in Childhood·Edward Thomas AndrewsMark P Tighe
Jun 2, 2011·Deutsches Ärzteblatt International·Philip BuflerHolm H Uhlig
Sep 24, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·John V CampoDavid A Brent
Aug 17, 2021·Pediatric Health, Medicine and Therapeutics·Craig FriesenJennifer V Schurman

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