Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents

The Journal of Pediatrics
Ron J BaharMarvin E Ament

Abstract

To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents. Adolescents 12 to 18 years with newly diagnosed IBS were surveyed with a symptom checklist, pain rating scale, visual analog scale, and IBS quality of life (QOL) questionnaire. Subjects were randomized in a double-blinded fashion to receive AMI or placebo, and again completed surveys at 2, 6, 10, and 13 weeks. Thirty-three patients (24 female) were enrolled. Patients receiving AMI were more likely to experience improvement from baseline in overall QOL at 6, 10, and 13 weeks (P = .019, .004, and .013). Patients receiving AMI were also more likely to experience a reduction in IBS-associated diarrhea at 6 and 10 weeks (P = .029 for both), a reduction in periumbilical pain at 10 weeks (P = .018), and a reduction in right lower quadrant pain at 6, 10, and 13 weeks (P = .014, .039, and .004). AMI significantly improves overall QOL in adolescents with IBS and should be a therapeutic option for adolescents with this disorder.

References

Aug 1, 1996·The Journal of Pediatrics·J S HyamsP A Andrulonis
Aug 24, 1999·Gut·A Rasquin-WeberA Staiano
Nov 7, 2000·Journal of Oral Rehabilitation·O PleshW D McCall
May 9, 2006·Gastroenterology·Andrée RasquinLynn S Walker
May 9, 2006·Gastroenterology·UNKNOWN Design of Treatment Trials CommitteeSander J O Veldhuyzen van Zanten

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Citations

Sep 1, 2009·World Journal of Pediatrics : WJP·Rana Fayez AmmouryJoseph Marino Croffie
Jan 15, 2014·Indian Pediatrics·Siba Prosad PaulDavid C A Candy
Jun 23, 2009·Journal of Pediatric Gastroenterology and Nutrition·Ann McGrath DavisPaul Hyman
Oct 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Michael Camilleri, Carlo Di Lorenzo
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Kok-Ann GweeUNKNOWN Asian Neurogastroenterology and Motility Association
Sep 8, 2012·Gastroenterology Research and Practice·Emanuele SinagraMario Cottone
Sep 14, 2012·Therapeutic Advances in Gastroenterology·Arvind Iyengar SrinathEva M Szigethy
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Helfried Rothuber, Bernhard Mitterauer
May 31, 2014·World Journal of Gastroenterology : WJG·Bhupinder Kaur Sandhu, Siba Prosad Paul
Aug 30, 2014·World Journal of Gastroenterology : WJG·Ashish Chogle, Miguel Saps
Jun 20, 2014·Paediatric Drugs·Adrian Miranda, Miguel Saps
Oct 12, 2014·Paediatric Drugs·Eapen MathewKenneth R Goldschneider
Jul 18, 2012·Child and Adolescent Psychiatric Clinics of North America·Bela GandhiJohn V Campo
Feb 22, 2011·Gastroenterology Clinics of North America·Madhusudan Grover, Douglas A Drossman
Nov 9, 2010·Advances in Pediatrics·Ian M Paul
Aug 4, 2010·Clinical Therapeutics·Megan FriedrichGeoffrey C Wall
Dec 17, 2009·The Journal of Pediatrics·Paul E Hyman, Javier Monagas
Sep 1, 2009·Gastroenterology·Marc A Benninga, Emeran A Mayer
Apr 11, 2014·Pediatric Annals·Ashish ChogleMiguel Saps
Feb 24, 2009·Gastrointestinal Endoscopy Clinics of North America·Madhusudan Grover, Douglas A Drossman
Nov 19, 2008·The Journal of Pediatrics·Yvonne van Leeuwen, Marjan Rafiee
May 7, 2011·Journal of Clinical Pharmacy and Therapeutics·K E Trinkley, M C Nahata
Sep 23, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H RoohafzaA Gholamrezaei
May 26, 2009·NeuroImage·Melissa A Rosenkranz, Richard J Davidson
Dec 3, 2014·The Journal of Pediatrics·Judith J KorterinkMerit M Tabbers
Feb 11, 2015·Nature Reviews. Gastroenterology & Hepatology·Judith KorterinkMarc A Benninga
May 5, 2016·Gastroenterology·Jeffrey S HyamsMiranda van Tilburg
Sep 3, 2016·Pediatrics in Review·Paul E Hyman
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M SapsC Di Lorenzo
Jun 3, 2014·Journal of Pediatric Gastroenterology and Nutrition·Sunny Z Hussain, Paul E Hyman
Feb 7, 2018·Expert Review of Gastroenterology & Hepatology·Shaman RajindrajithMarc A Benninga
Apr 11, 2018·Expert Review of Gastroenterology & Hepatology·Shivani GuptaMiguel Saps
Mar 7, 2017·The Cochrane Database of Systematic Reviews·Alice E MartinStuart Logan
Aug 6, 2017·The Cochrane Database of Systematic Reviews·Tess E CooperPhilip J Wiffen
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Angela KaminskiGerald Gartlehner
Feb 23, 2018·Journal of Pediatric Gastroenterology and Nutrition·Rebecca A AbbottStuart Logan
Aug 26, 2011·Journal of Pediatric Gastroenterology and Nutrition·Jonathan E Teitelbaum, Ruchi Arora
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Paul E Hyman
Mar 3, 2018·Paediatric Drugs·Andrea BrusaferroSusanna Esposito
Jun 10, 2010·Expert Review of Gastroenterology & Hepatology·Eric Chiou, Samuel Nurko
Jul 23, 2013·Current Opinion in Psychiatry·Kasia Kozlowska

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