Double-Blind Prospective Randomized Controlled Trial of Dopamine Versus Epinephrine as First-Line Vasoactive Drugs in Pediatric Septic Shock

Critical Care Medicine
Andréa M C VenturaAlfredo E Gilio

Abstract

The primary outcome was to compare the effects of dopamine or epinephrine in severe sepsis on 28-day mortality; secondary outcomes were the rate of healthcare-associated infection, the need for other vasoactive drugs, and the multiple organ dysfunction score. Double-blind, prospective, randomized controlled trial from February 1, 2009, to July 31, 2013. PICU, Hospital Universitário da Universidade de São Paulo, Brazil. Consecutive children who are 1 month to 15 years old and met the clinical criteria for fluid-refractory septic shock. Exclusions were receiving vasoactive drug(s) prior to hospital admission, having known cardiac disease, having already participated in the trial during the same hospital stay, refusing to participate, or having do-not-resuscitate orders. Patients were randomly assigned to receive either dopamine (5-10 μg/kg/min) or epinephrine (0.1-0.3 μg/kg/min) through a peripheral or intraosseous line. Patients not reaching predefined stabilization criteria after the maximum dose were classified as treatment failure, at which point the attending physician gradually stopped the study drug and started another catecholamine. Physiologic and laboratory data were recorded. Baseline characteristics were described as ...Continue Reading

Associated Clinical Trials

References

Jan 1, 1989·Critical Care Medicine·J A CarcilloA I Fields
Apr 1, 1984·Annals of Internal Medicine·M M ParkerJ E Parrillo
Nov 1, 1994·Critical Care Medicine·G Van den BergheP Lauwers
Aug 1, 1998·Pediatrics·G CenevivaJ A Carcillo
Oct 24, 1998·Journal of Accident & Emergency Medicine·S NadelM Levin
May 17, 2001·Critical Care : the Official Journal of the Critical Care Forum·P Y Cheung, K J Barrington
Feb 28, 2002·The Journal of Pediatrics·David OsbornMartin Kluckow
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Jul 29, 2003·Current Opinion in Critical Care·Karl TrägerPeter Radermacher
Mar 17, 2004·The American Journal of Cardiology·James J JoyceBarry G Baylen
Nov 16, 2004·Critical Care Medicine·Richard J BealeJoseph E Parrillo
Mar 3, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Luca FilippiCristina Santoro
May 27, 2008·Intensive Care Medicine·Andrea WolflerUNKNOWN Italian Pediatric Sepsis Study (SISPe) group
Dec 31, 2008·Critical Care Medicine·Pedro R PóvoaUNKNOWN Portuguese Community-Acquired Sepsis Study Group
Jan 10, 2009·Archives of Disease in Childhood·D P InwaldUNKNOWN Paediatric Intensive Care Society Study Group (PICS-SG)
Nov 1, 2011·Critical Care Medicine·Daniel De BackerJean-Louis Vincent
Mar 31, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Juan C Jaramillo-BustamanteJosé Bareño-Silva
Oct 7, 2011·The Open Inflammation Journal·Derek S WheelerBasilia Zingarelli
Jul 31, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanR Scott Watson
Apr 9, 2014·Pediatrics·Raina PaulMark I Neuman

❮ Previous
Next ❯

Citations

Mar 8, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Waleed AlqurashiKusum Menon
Sep 27, 2016·Critical Care : the Official Journal of the Critical Care Forum·Samiran RayMark J Peters
Nov 11, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Suchitra RanjitPaul E Marik
Jan 19, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kusum MenonKaren Choong
Feb 6, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·José Colleti, Werther Brunow de Carvalho
Feb 6, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Karthik N Ramaswamy, Sunit C Singhi
Jan 11, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Takeshi HatachiMuneyuki Takeuchi
Mar 3, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Srinivas Murthy
Jul 21, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alan L DavisAaron L Zuckerberg
Aug 15, 2017·Journal of Clinical Medicine·Travis J MaticsJason M Kane
Feb 3, 2018·Surgical Infections·Bryanna M EmrKevin P Mollen
Aug 30, 2019·Current Opinion in Pediatrics·Ericka L Fink, Robert C Tasker
Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
Jan 16, 2016·Critical Care Medicine·Saptharishi Lalgudi Ganesan, Muralidharan Jayashree
Jan 16, 2016·Critical Care Medicine·Andrea Cordeiro Ventura, Huei Hsin Shieh
Nov 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ricardo Garcia Branco
Sep 28, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Karthik Narayanan RamaswamyKarthi Nallasamy
Oct 18, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Julie C FitzgeraldNiranjan Kissoon
Nov 11, 2018·Archives of Disease in Childhood·Steven McVea, Alastair Turner
Sep 16, 2017·Intensive Care Medicine·Andrew C ArgentSuchitra Ranjit
Apr 18, 2020·Critical Care Medicine·Robert B LindellJulie C Fitzgerald
Apr 16, 2016·Critical Care Medicine·Katherine N SlainAlexandre T Rotta
Apr 16, 2016·Critical Care Medicine·Niina KleiberSaskia N de Wildt
Sep 23, 2018·Critical Care : the Official Journal of the Critical Care Forum·Stefanie G AmesJoseph A Carcillo
Sep 19, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kaitlin Hughes, Lauren Buenger
Nov 7, 2019·Current Opinion in Pediatrics·Ericka L Fink, Robert C Tasker
May 28, 2020·European Journal of Pediatrics·Masashi HottaKazuko Wada
Sep 2, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jessica S WallischRajesh K Aneja
Mar 21, 2017·Intensive Care Medicine·Mark J PetersJacques Lacroix
Aug 21, 2020·Seminars in Respiratory and Critical Care Medicine·James A RussellNiranjan Kissoon
Apr 16, 2016·Critical Care Medicine·Andrea Cordeiro Ventura, Albert Bousso
Feb 1, 2018·Pediatric Emergency Care·Drew Taylor Louden, Lori Ellen Rutman
Jul 22, 2017·Journal of Intensive Care·Tatsuya Kawasaki
Jun 30, 2019·Annals of Intensive Care·Luc MorinUNKNOWN ESPNIC Refractory Septic Shock Definition taskforce and the Infection, Systemic Inflammation and Sepsis ESPNIC section
Mar 23, 2017·Expert Review of Anti-infective Therapy·Stavroula Ilia, George Briassoulis
Feb 8, 2019·Frontiers in Pediatrics·Nchafatso Gikenyi ObonyoJohn Francis Fraser
Aug 10, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniela Carla de Souza, Vanessa Soares Lanziotti
Oct 22, 2020·Circulation·Raina M MerchantUNKNOWN Adult Basic and Advanced Life Support, Pediatric Basic and Advanced Life Support, Neonatal Life Support, Resuscitation Educa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Felipe Cezar CabralJefferson Pedro Piva
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Flávia F PanicoWerther Brunow de Carvalho
© 2021 Meta ULC. All rights reserved