Double-blind prospective randomized study comparing topical mupirocin and placebo for the prevention of infection associated with central venous catheters.

The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses
J M ConlyB Peters

Abstract

To compare the incidence of exit site colonization, local catheter-related infection and catheter-related bacteremia in patients randomized to receive either topical 2% mupirocin or placebo at the catheter exit site. Patients requiring central venous catheters for more than three days were randomized to receive in a double-blind fashion either topical mupirocin or an identical placebo at the exit site three times weekly at the time of dressing change. Insertion, site care and removal of catheters were standardized. Serial semiquantitataive cultures of the skin at the catheter insertion site were performed using a sterile 25 cm(2) template. The distal and proximal catheter segments were cultured using a standardized semiquantitative technique, and any suspect catheter-related bacteremia was investigated with two sets of peripheral blood cultures, a 10 mL sample of infusate and clinical assessment. Both univariate and multivariate analyses were conducted on individual risk factors to determine factors that might influence the outcomes of local or systemic catheter-related infection. Local catheter-related infection (defined as more than 15 colony forming units [cfu] on culture of the proximal or distal catheter segment) occurred ...Continue Reading

Citations

Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A HumarJ M Conly

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