PMID: 8605897Oct 1, 1995Paper

Double-blind randomized study of 1 g versus 2 g intravenous ceftriaxone daily in the therapy of community-acquired infections

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
S SegevS Pitlik

Abstract

In a multicentre, double-blind, randomized study involving four general hospitals in Israel, the efficacy and safety of ceftriaxone 1 g/day i.v. was compared to that of 2 g/day i.v. in the treatment of moderate to severe community-acquired infections requiring hospitalization. Two hundred and twenty-two patients were enrolled; 112 received intravenous ceftriaxone 1 g/day, and 110 received 2 g/day. The two groups were matched demographically, and their mean APACHE II score (10 points) and mean duration of successful therapy (7 days) were identical. The sites of infection in the 1 g and 2 g groups respectively were lower respiratory tract in 57 versus 51 patients, urinary tract in 31 versus 40 patients, and soft tissue in 24 versus 19 patients. There were no significant differences in clinical outcome between the 1 g and 2 g groups, the outcome being cure in 91% versus 86% of patients, improvement in 3% versus 3% of patients, failure in 3% versus 8% of patients, and relapse in 3% versus 3% of patients. The findings of this study indicate that ceftriaxone 1 g/day is as effective as 2 g/day in the treatment of moderate to severe community-acquired infections. The low-dose form is a more economical means of treating these infections.

References

Oct 1, 1990·The Journal of Antimicrobial Chemotherapy·S SegevE Rubinstein
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·G F AbbateE Catena
Jan 1, 1986·Chemotherapy·F FraschiniD Esposti
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Dec 1, 1984·The Journal of Antimicrobial Chemotherapy·F P MaesenJ P Teengs

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Citations

Jul 27, 1999·International Journal of Antimicrobial Agents·G J de KlerkA I Hoepelman
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Guillermo Ortiz-RuizUNKNOWN Protocol 018 Ertapenem Community-Acquired Pneumonia Study Group
Dec 23, 2003·Journal of the American Geriatrics Society·Gail L WoodsIan R Friedland
Mar 25, 2020·Antimicrobial Agents and Chemotherapy·Andrew AckermanThomas J Dilworth

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