Double-blind study to evaluate efficacy and safety of meloxicam 7.5 mg and 15 mg versus mefenamic acid 1500 mg in the treatment of primary dysmenorrhea

Acta Obstetricia Et Gynecologica Scandinavica
Nilson Roberto de MelloRoberto Jose Risco Cortes

Abstract

Assessment of efficacy and safety of meloxicam 7.5 mg and 15 mg once a day (o.a.d.) compared with mefenamic acid 500 mg three times a day (t.i.d.), over a treatment period of 3-5 days, during three menstrual cycles, for primary dysmenorrhea. Multicenter, multinational, double-blind, double-dummy, three parallel groups, randomized trial, phase IIb, 337 patients. Treatment group comparisons of continuous variables were carried out using the Kruskal-Wallis test and Wilcoxon signed rank tests. Efficacy was analyzed using Fisher and chi(2)-tests. Meloxicam 7.5 mg and 15 mg showed a similar profile in pain reduction and dysmenorrhea symptoms when compared with mefenamic acid. Thirty-five subjects presented with gastrointestinal (GI) adverse events (AEs). Two-thirds of those 35 subjects were in the mefenamic acid group. There were no differences between the safety profiles of the two meloxicam dosages. Laboratory abnormalities did not differ in incidence among the treatment groups. Both of the daily doses of meloxicam tested were comparable to 500 mg mefenamic acid t.i.d. in relieving dysmenorrhea symptoms, and meloxicam seems to have a better gastrointestinal tolerability profile.

References

Apr 1, 1978·American Journal of Obstetrics and Gynecology·O Ylikorkala, M Y Dawood
May 1, 1976·Prostaglandins·V LundströmN Wiqvist
May 8, 1991·Biochimica Et Biophysica Acta·D L DeWitt
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·M Y Dawood
Jan 1, 1970·American Journal of Obstetrics and Gynecology·W W Filler, W C Hall
Jul 1, 1969·Health Physics·N Ohen, T J Kneip
Nov 15, 1982·American Journal of Obstetrics and Gynecology·B Andersch, I Milsom
Jan 1, 1994·Pharmacology & Toxicology·J DelgadoJ Yoma
Jan 20, 1994·Nature·J Vane
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerK Seibert
Nov 1, 1993·American Journal of Obstetrics and Gynecology·M Y Dawood
Dec 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C BieglmayerH Janisch
Apr 1, 1996·British Journal of Rheumatology·M DistelJ Fries
Dec 24, 1997·Pediatric Clinics of North America·B J O'Connell
Mar 13, 1998·Cephalalgia : an International Journal of Headache·P L VenturiniG Ginocchio
Aug 6, 1998·British Journal of Obstetrics and Gynaecology·W Y Zhang, A Li Wan Po
Aug 26, 1998·Rheumatic Diseases Clinics of North America·T J Smith
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M H PillingerG Weissmann
Jun 29, 1999·Pediatric Clinics of North America·B Schroeder, J S Sanfilippo
Jul 27, 1999·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·T I HillenJ M Keogh
Apr 1, 1965·The Journal of Obstetrics and Gynaecology of the British Commonwealth·V R PICKLESG N SMITH
Jan 1, 1996·Mediators of Inflammation·Y S Bakhle, R M Botting

❮ Previous
Next ❯

Citations

Jul 27, 2006·Allergy·S WöhrlG Stingl
Oct 4, 2005·Expert Opinion on Pharmacotherapy·Brian J GatesNeal M Davies
Mar 10, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Lira-PlascenciaS Carranza-Lira
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Jane MarjoribanksMichelle Proctor
May 10, 2013·Expert Review of Clinical Pharmacology·Nevio Cimolai
Jul 19, 2016·International Journal of Adolescent Medicine and Health·Fariba GhaderiMohammad Ali Mohseni Bandpei
Apr 19, 2020·Hormone Molecular Biology and Clinical Investigation·Nurul Iftida BasriNor Azlin Mohamed Ismail

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Giti OzgoliFariborz Moattar
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
G A Kintis, B Coutifaris
© 2022 Meta ULC. All rights reserved