PMID: 93180Dec 15, 1979

Double-blind trial of antihypertensive effect of chlorothiazide in severe renal failure

Lancet
B Jones, R S Nanra

Abstract

A randomised double-blind crossover trial was done to assess the efficacy of chlorothiazide as an antihypertensive drug in patients with severe renal failure. There was a significant reduction in standing (mean drop 13/6 mm Hg) and supine (mean drop 13/5 mm Hg) blood-pressure, without postural hypotension. Chlorothiazide has a place in the management of hypertension in patients with severe renal failure and its antihypertensive effect is probably due to a change in peripheral vascular resistance and not to volume contraction.

Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·I S SketrisM C Meyer
May 24, 1980·Lancet·R F Harvey, M J Bradshaw
May 24, 1980·Lancet·B Jones, R S Nanra
Feb 15, 2008·Journal of the American Society of Nephrology : JASN·Liffert VogtGerjan Navis
Feb 14, 2016·Current Opinion in Pharmacology·Mohamed H Shahin, Julie A Johnson
Jan 28, 2009·Journal of the American Geriatrics Society·Joseph T HanlonSteven M Handler
Jan 29, 1988·The American Journal of Medicine·Frans H H LeenenA Marquez-Julio
Aug 1, 1986·Australian and New Zealand Journal of Medicine·A DavisE J Begg
Apr 2, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alun D Hughes
Dec 16, 1989·BMJ : British Medical Journal·P L Hall
Dec 16, 1989·BMJ : British Medical Journal·B F Jones
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·B Odlind
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·P Hjemdahl
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·M Danielson
Jun 8, 2015·Current Opinion in Cardiology·Arjun D Sinha, Rajiv Agarwal
Jan 31, 2020·Journal of the American Society of Nephrology : JASN·Dominique M BovéeEwout J Hoorn
Mar 18, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Douglas L Blowey
Nov 6, 2015·American Journal of Physiology. Renal Physiology·Simone Costa Alarcon AriasRoberto Zatz

Related Concepts

Diastolic Blood Pressure
Clinical Trials
Hypertensive Disease
Kidney
Kidney Failure, Chronic
Placebos
Pulmonary Vascular Resistance

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.