PMID: 93180Dec 15, 1979

Double-blind trial of antihypertensive effect of chlorothiazide in severe renal failure

B Jones, R S Nanra


A randomised double-blind crossover trial was done to assess the efficacy of chlorothiazide as an antihypertensive drug in patients with severe renal failure. There was a significant reduction in standing (mean drop 13/6 mm Hg) and supine (mean drop 13/5 mm Hg) blood-pressure, without postural hypotension. Chlorothiazide has a place in the management of hypertension in patients with severe renal failure and its antihypertensive effect is probably due to a change in peripheral vascular resistance and not to volume contraction.


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Related Concepts

Diastolic Blood Pressure
Clinical Trials
Hypertensive Disease
Kidney Failure, Chronic
Pulmonary Vascular Resistance

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