PMID: 2504171Aug 1, 1989Paper

Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis

Arthritis and Rheumatism
G W CannonL Cogen

Abstract

One hundred five patients were enrolled in a 12-week, randomized, prospective, double-blind, placebo-controlled trial of recombinant human gamma-interferon (rHu gamma-IFN) for the treatment of rheumatoid arthritis. Fifty-four patients received rHu gamma-IFN and 51 received placebo. Forty-two patients in each group completed the 12-week trial. Some clinical improvement occurred in both groups of patients. Although the improvement with rHu gamma-IFN was greater than that with placebo, the differences were generally not statistically significant.

References

Jul 5, 1979·The New England Journal of Medicine·J J HooksA L Notkins
Aug 29, 1986·Deutsche medizinische Wochenschrift·G Fierlbeck, G Rassner
Apr 1, 1987·The Journal of Clinical Investigation·R D GransteinE P Amento
Nov 1, 1985·Seminars in Arthritis and Rheumatism·G W CannonD O Clegg
Feb 1, 1985·Arthritis and Rheumatism·G Husby, R C Williams
Nov 15, 1985·Deutsche medizinische Wochenschrift·H J Obert, P H Hofschneider
Jan 1, 1974·Annals of Internal Medicine·J W SiglerW R McCrum
Jul 10, 1980·Nature
Jan 1, 1982·Annual Review of Biochemistry·P Lengyel
Dec 1, 1983·Annals of the Rheumatic Diseases·M DeGréO Clarke-Jenssen
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Dec 24, 1955·Journal of the American Medical Association·H K BEECHER
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN
Apr 1, 1985·Immunology Today·G Trinchieri, B Perussia

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Citations

Mar 1, 1997·Arthritis and Rheumatism·L W MorelandW J Koopman
Jan 1, 1994·Biotherapy·L C Miller
Dec 1, 1990·Baillière's Clinical Rheumatology·B Kirkham, G S Panayi
Jun 21, 2011·Nature Immunology·Vanja Lazarevic, Laurie H Glimcher
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kiran NistalaLucy R Wedderburn
Sep 13, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Evelien SchurgersPatrick Matthys
Jan 23, 1998·Journal of Women's Health·J M Grossman, E Brahn
Apr 23, 2003·Current Opinion in Rheumatology·Edward C Keystone
Dec 1, 1995·Annals of the Rheumatic Diseases·H R Barthel, G R Burmester
Dec 19, 2006·The Journal of Clinical Investigation·Yuhao GaoRoberto Pacifici
Nov 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuhao GaoRoberto Pacifici
Jun 24, 2004·Expert Opinion on Pharmacotherapy·Andreas Otto Reiff
Apr 30, 1998·Annals of Medicine·P Isomäki, J Punnonen
Jul 13, 2006·Annals of the New York Academy of Sciences·M Neale Weitzmann, Roberto Pacifici
Nov 30, 2005·Immunological Reviews·M Neale Weitzmann, Roberto Pacifici
Jan 27, 2012·The Journal of Investigative Dermatology·Leanne M Johnson-HuangMichelle A Lowes
Aug 18, 2004·The Journal of Clinical Investigation·Gary S Firestein
Apr 10, 2015·Current Rheumatology Reports·Ignacio García-De LaTorre, Ignacio García-Valladares
Apr 26, 2017·Cytokine·Eugene Y Kim, Kamal D Moudgil
Feb 1, 1995·Archives of Physical Medicine and Rehabilitation·E L Semble
Feb 2, 2008·Arthritis and Rheumatism·William J Koopman
Jan 25, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roberto Pacifici
Sep 4, 2017·Annals of the Rheumatic Diseases·Wen-Xiu MoXuan Zhang
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ingo M IrmlerRolf Bräuer
Jun 1, 1991·Annals of the Rheumatic Diseases·P KahleG Pawelec
Sep 1, 1990·Clinical and Experimental Immunology·H NakajimaW Tsukada
Nov 9, 2000·Osteoarthritis and Cartilage·Y E HenrotinJ Y Reginster

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