PMID: 9555823Apr 29, 1998Paper

Double-blind, vehicle-controlled, multicenter comparison of two 0.025% tretinoin creams in patients with acne vulgaris

Journal of the American Academy of Dermatology
A W LuckyM E Reddick

Abstract

Preclinical study and human patch tests indicate polyolprepolymer-2 may reduce cutaneous tretinoin-induced irritation. This study compared the clinical efficacy and safety of a 0.025% tretinoin cream containing polyolprepolymer-2 and its vehicle to a commercially-available 0.025% tretinoin cream. In this 12-week multicenter, double-blind, parallel group study in patients with mild to moderate acne, objective lesion counts and the investigators' global evaluations evaluated efficacy. Subjective evaluations of skin irritation were used to study safety. A total of 271 patients were enrolled. The active treatments demonstrated comparable efficacy that was statistically significantly greater than that of the vehicle. Safety evaluations of cutaneous and noncutaneous adverse events also indicated comparable results of the active treatments. The commercially-available 0.025% tretinoin cream and the 0.025% tretinoin cream containing polyolprepolymer-2 demonstrated comparable efficacy and safety.

References

Jun 1, 1990·International Journal of Dermatology·G F Webster
Apr 1, 1969·Archives of Dermatology·A M KligmanG Plewig
Apr 17, 1997·The New England Journal of Medicine·J J Leyden

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Citations

Jun 24, 2008·Pediatric Dermatology·Andrew C KrakowskiLawrence F Eichenfield
Apr 2, 2014·TheScientificWorldJournal·Amber VyasBina Gidwani
Feb 22, 2016·Journal of the American Academy of Dermatology·Andrea L ZaengleinKevin M Boyer
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastUNKNOWN European Dermatology Forum
Nov 24, 2004·Clinics in Dermatology·Andrea Krautheim, Harald P M Gollnick
Jan 8, 2000·Dermatologic Clinics·D M Thiboutot
Apr 29, 1998·Journal of the American Academy of Dermatology·J J Leyden
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
May 16, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anja ThielitzHarald Gollnick
Jan 30, 2003·American Journal of Clinical Dermatology·Larry E Millikan
Jun 20, 2003·American Journal of Clinical Dermatology·Arash Akhavan, Susan Bershad
May 14, 2011·Postgraduate Medicine·Peter HsuRobert T Brodell
Oct 9, 2012·American Journal of Clinical Dermatology·April W ArmstrongClayton W Schupp
Mar 23, 2000·Postgraduate Medicine·B A Johnson, J R Nunley
Jun 21, 2007·Journal of Microencapsulation·Gisele A CastroLucas A M Ferreira
May 25, 2021·Annales pharmaceutiques françaises·S MalaviJ Dwivedi
Sep 5, 2006·Pediatrics·Andrea L Zaenglein, Diane M Thiboutot

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