PMID: 10687923Feb 25, 2000

Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals

Mechanisms of Ageing and Development
Reinald PamplonaGustavo Barja


Free radical damage is currently considered a main determinant of the rate of aging. Unsaturated fatty acids are the tissue macromolecules most sensitive to oxidative damage. Therefore, the presence of relatively low degrees of fatty acid unsaturation is expected in the tissues of longevous animals. In agreement with this prediction, fatty acid analyses of heart phospholipids in eight mammals ranging in maximum life span (MLSP) from 3.5 to 46 years showed that their total number of double bonds is negatively correlated with MLSP (r = -0.78, P < 0.02). The low double content of longevous mammals was not due to a low polyunsaturated fatty acid content. Instead, it was mainly due to a redistribution between types of polyunsaturated fatty acids from the highly unsaturated docosahexaenoic acid (22:6n-3) to the less unsaturated linoleic acid (18:2n-6) in longevous animals (r = -0.89, P < 0.003 for 22:6n-3 and r = 0.91, P < 0.002 for 18:2n-6 versus MLSP), where n = number of different animals in each species. This redistribution suggests that one of the mechanisms responsible for the low number of fatty acid double bonds is the presence of low desaturase activities in longevous animals, although other causing factors must be involved....Continue Reading


May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R G Cutler
Jan 1, 1984·Progress in Lipid Research·R R Brenner
Jun 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·Martin D BrandA J Hulbert
Oct 14, 1993·Nature·B Maresca, A R Cossins
Nov 1, 1995·The Journal of Membrane Biology·Patrice Couture, A J Hulbert
Jul 5, 1996·Science·R S Sohal, R Weindruch
Feb 19, 1998·Experimental Gerontology·D Harman


Feb 22, 2001·Bulletin of Experimental Biology and Medicine·V K Khavinson, S V Myl'nikov
Mar 3, 2005·Aging Clinical and Experimental Research·Ilaria TamburiniEttore Bergamini
Jul 31, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Eran LevinNoga Kronfeld-Schor
Jul 22, 2005·Biogerontology·R Holliday
Aug 21, 2013·Biogerontology·Vanessa Gonzalez-Covarrubias
Oct 26, 2002·Free Radical Biology & Medicine·Gustavo Barja
Feb 13, 2001·Trends in Biochemical Sciences·R Holliday
Jul 2, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A J HulbertPatrice Couture
May 9, 2006·Antioxidants & Redox Signaling·Alberto SanzGustavo Barja
Jun 6, 2009·Antioxidants & Redox Signaling·Anne Negre-SalvayreManuel Portero-Otín
Jun 25, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robin Holliday
Mar 3, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tapiwanashe MagwereLinda Partridge
May 24, 2014·Longevity & Healthspan·Martin D Brand
Jan 15, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christopher M MulliganAdam J Chicco
Jun 3, 2014·BioMed Research International·Giusi Taormina, Mario G Mirisola
Aug 10, 2010·Mitochondrion·Hélène LemieuxP U Blier
Dec 8, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·András SzabóHedvig Fébel
Sep 13, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Urszula PaslawskaKatarzyna Michlik
Mar 13, 2016·Lipids·Gabriella CavalliniEttore Bergamini
Dec 13, 2006·Aging Cell·Teresa G Valencak, Thomas Ruf
Jul 27, 2015·Revista española de geriatría y gerontología·Adrian González-AlonsoJosé L Quiles
Dec 27, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jeffrey A Stuart, Melanie F Brown
Oct 24, 2006·Aging Cell·Blazej AndziakRochelle Buffenstein
Mar 5, 2013·Aging Cell·Vanessa Gonzalez-CovarrubiasEline P Slagboom
Nov 13, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·H LemieuxJ-C Tardif
Dec 29, 2000·Aging : Clinical and Experimental Research·Gustavo Barja
Oct 19, 2017·Journal of Lipid Research·Douglas BorchmanJ Craig George
May 9, 2009·Age·L J Furness, John R Speakman
Sep 4, 2004·Neurosurgical Focus·Parameswaran S BhattathiriAlexander D Mendelow
Oct 12, 2007·Physiological Reviews·A J HulbertW A Buttemer
Mar 20, 2002·Current Neurology and Neuroscience Reports·G L Bernardini, E M DeShaies
Apr 27, 2002·Annals of the New York Academy of Sciences·Simon Melov
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Qin-Li WanGui-Sheng Wu
Apr 27, 2002·Annals of the New York Academy of Sciences·Reinald PamplonaManuel Portero-Otín
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariona JovéReinald Pamplona
Feb 26, 2019·Conservation Physiology·Shannon E CurrieNicolas J Fasel

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