Double CD38- /CD138- negative multiple myeloma

Hematology/oncology and Stem Cell Therapy
Vitaliy MykytivNurul Asyikin Mohd Hashim

Abstract

The standard diagnosis of multiple myeloma by flow cytometry is based on selection of population of CD38+/CD138+ positives cells. As the result treatment with proteasome inhibitors, CD138 may be underexpressed on atypical plasma cells. Thus, in order to improve this strategy, recently new CD138-independent method, based on CD38 positivity of plasma cells was developed. We present an unusual case of CD138- negative multiple myeloma which had become double CD138-/CD38- negative after treatment with daratumumab by which we would like to illustrate potential pitfalls of both strategies.

Citations

Nov 7, 2019·Molecular Cancer·Quande LinDelong Liu
Nov 4, 2020·Journal of Hematology & Oncology·David T OmsteadBasar Bilgicer
Jan 1, 2020·Expert Review of Precision Medicine and Drug Development·Matthew HoKenneth C Anderson

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