Double dissociation between lab measures of inattention and impulsivity and the dopamine transporter gene (DAT1) and dopamine D4 receptor gene (DRD4)

Journal of Abnormal Psychology
Ian R Gizer, Irwin D Waldman

Abstract

Studies examining the biological and neuropsychological processes underlying attention-deficit/hyperactivity disorder (ADHD) suggest that error indices from the A-X Continuous Performance Test (A-X CPT) might represent useful endophenotypes for ADHD. The current study extended such findings by evaluating the utility of these putative endophenotypes in the context of a molecular genetic study. One hundred and forty-eight clinic-referred ADHD probands and 56 siblings were recruited as part of an ongoing study. Between- and within-family tests of association were conducted to test for relations between polymorphisms in two candidate genes, the dopamine transporter gene (DAT1) and the dopamine D4 receptor gene (DRD4), and indices of inattention and impulsivity derived from the A-X CPT. Association analyses of these polymorphisms with the A-X CPT indices suggested a double dissociation such that an index of inattention was associated with DRD4 but not DAT1, and an index of impulsivity was associated with DAT1 but not DRD4. Further analyses suggested that an A-X CPT index of impulsivity partially mediated previously observed associations between hyperactive-impulsive ADHD symptoms and DAT1. Additionally, an A-X CPT index of inattenti...Continue Reading

Citations

Feb 14, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Björn AlbrechtTobias Banaschewski
Aug 8, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Anna-Maria KasparbauerUlrich Ettinger
Jun 20, 2014·Neuropsychologia·Yunsoo Park, Irwin D Waldman
Sep 23, 2014·Journal of Cognitive Neuroscience·Marissa A GorlickW Todd Maddox
Nov 20, 2016·Journal of Attention Disorders·Sergio Luís SchmidtAna Lúcia Novais Carvalho
Apr 12, 2020·Scientific Reports·Katarzyna KucAnita Cybulska-Klosowicz
Feb 26, 2019·Frontiers in Human Neuroscience·Yuyang LuoXiaobo Li
Feb 27, 2021·Behavioural Brain Research·Macarena MorenoJosé Antonio Fuentealba

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