PMID: 9189269Jun 1, 1997Paper

Double dissociation of hippocampal and dorsal-striatal memory systems by posttraining intracerebral injections of 2-amino-5-phosphonopentanoic acid

Behavioral Neuroscience
M G Packard, L A Teather

Abstract

Rats received an 8-trial training session on a spatial or cued task in a water maze, followed by a posttraining intracerebral injection of AP5 or saline. On a retention test 24 hr later, latency to mount the escape platform was used as a measure of memory. Intrahippocampal (10 micrograms), but not intra-dorsal striatal (2, 5, or 10 micrograms), injection of AP5 impaired memory in the spatial task. In contrast, intra-dorsal striatal (2 micrograms), but not intrahippocampal (2, 5, or 10 micrograms) injection of AP5 impaired memory in the cued task. Intracerebral injections of AP5 delayed 2 hr posttraining were ineffective. The findings indicate a double dissociation of the roles of the hippocampus and dorsal striatum in memory, a role for N-methyl-D-aspartate receptor function in posttraining memory processes, and a glutamatergic modulation of both hippocampal and dorsal striatal memory processes, suggesting that different forms of memory may share a similar neurochemical basis.

Citations

Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lisa A Teather, Richard J Wurtman
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M G Packard
Mar 20, 2002·Behavioral Neuroscience·Michael E RagozzinoRaymond P Kesner
Mar 28, 2002·Learning & Memory·Lisa A TeatherNicolas G Bazan
May 15, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G M MorrisC O'Carroll
Dec 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrei T PopescuDenis Paré
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anni S LeeChristopher Pittenger
May 12, 2009·Nature Neuroscience·Andrei T PopescuDenis Paré
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Valentina FerrettiAndrea Mele
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Qin GongXiao-Hui Zhang
Jun 8, 2002·Annual Review of Neuroscience·Mark G Packard, Barbara J Knowlton

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