Double-edged alliance: mitochondrial surveillance by the UPS and autophagy.

Current Opinion in Cell Biology
André FranzThorsten Hoppe

Abstract

Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death. Consequently, fast adaptation to metabolic changes associated with developmental demands or stress induction requires a balanced coordination of mitochondrial biogenesis and removal of damaged mitochondria. Impaired mitochondrial maintenance is causally linked to many human pathologies and aging, including diabetes, cancer, and neurodegenerative diseases. Thus, it is of fundamental importance to understand cellular surveillance mechanisms that support a healthy mitochondrial network. In this review, we discuss the role of ubiquitin-dependent protein degradation in mitochondrial functionality.

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Jan 20, 2016·International Journal of Molecular Sciences·Young Mi SongByung-Wan Lee
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May 12, 2020·Frontiers in Cell and Developmental Biology·Sonia RavanelliThorsten Hoppe
Nov 20, 2020·Biomolecules·Prasad SulkshaneMichael H Glickman

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