Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia

Frontiers in Molecular Neuroscience
Chuanjun ZhuoLi Zhang

Abstract

Schizophrenia (SCZ) is a common psychiatric disorder with polygenetic pathogenesis. Among the many identified candidate genes and loci, the group of tumour suppressor genes has drawn our interest. In this mini-review article, we describe evidence of a correlation between major tumour suppressor genes and SCZ development. Genetic mutations ranging from single nucleotide polymorphisms to large structural alterations have been found in tumour-related genes in patients with SCZ. Epigenetic mechanisms, including DNA methylation/acetylation and microRNA regulation of tumour suppressor genes, have also been implicated in SCZ. Beyond genetic correlations, we hope to establish causal relationships between tumour suppressor gene function and SCZ risk. Accumulating evidence shows that tumour suppressor genes may mediate cell survival and neural development, both of which contribute to SCZ aetiology. Moreover, converging intracellular signalling pathways indicate a role of tumour suppressor genes in SCZ pathogenesis. Tumour suppressor gene function may mediate a direct link between neural development and function and psychiatric disorders, including SCZ. A deeper understanding of how neural cell development is affected by tumour suppressor...Continue Reading

References

Jan 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·H HäfnerA Riecher-Rössler
Jun 29, 2001·Archives of General Psychiatry·D LichtermannJ Lönnqvist
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tao SuI Bernard Weinstein
Nov 12, 2003·Schizophrenia Bulletin·Louis A Sass, Josef Parnas
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Jan 28, 2005·Neurochemical Research·Jessie S Chambers, Nora I Perrone-Bizzozero
Jul 26, 2005·Neuroscience Letters·Xingqun NiJames L Kennedy
Apr 22, 2006·Schizophrenia Research·Vibeke Sørensen CattsLouise Helen Lutze-Mann
Jan 30, 2007·Current Opinion in Neurobiology·Shaun MackieDavid J Porteous
Feb 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·I LevavH Werner
Jun 8, 2007·Biological Psychiatry·Petroula ProitsiSimon Lovestone
Jun 15, 2007·Journal of Psychiatric Research·Shusuke NumataTetsuro Ohmori
Oct 9, 2007·Acta Psychiatrica Scandinavica·S LeuchtN Sartorius
Mar 12, 2008·Acta Psychiatrica Scandinavica·V S CattsA D J Frost
Aug 22, 2008·Schizophrenia Research·Jiajun ShiChunyu Liu
May 5, 2009·Cell·Karen H Vousden, Carol Prives
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Sep 25, 2009·Nature Reviews. Cancer·Arnold J Levine, Moshe Oren
Nov 18, 2009·The American Journal of Psychiatry·Zachary FreybergJonathan A Javitch
Sep 28, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Martin TesliOle A Andreassen
Dec 22, 2010·Cell Adhesion & Migration·Soo-Young KimHyun Kim
Apr 15, 2011·Nature·Kristen J BrennandFred H Gage
Aug 9, 2011·Autism Research : Official Journal of the International Society for Autism Research·B Crespi
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dadi JiangLaura D Attardi
Feb 22, 2012·Frontiers in Behavioral Neuroscience·Hisatsugu KoshimizuTsuyoshi Miyakawa
Mar 16, 2012·Schizophrenia Research·Alanna GrantCecilia Flores
May 25, 2012·Schizophrenia Research·Gilad GalItzhak Levav
Aug 7, 2012·Nature Neuroscience·Mitsumasa KuritaJavier González-Maeso
Nov 20, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nibaldo C InestrosaMarco Fuenzalida
Dec 6, 2012·Schizophrenia Bulletin·Emma DempsterJonathan Mill

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Citations

Oct 2, 2020·Physiological Reviews·Rico SchieweckMichael A Kiebler
Nov 19, 2021·Purinergic Signalling·Manuel F MuñozJorge E Contreras
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans
Dec 15, 2021·Journal of the American Association for Laboratory Animal Science : JAALAS·Anne L MerleyLynn Collura Impelluso

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