Double filtration plasmapheresis in antibody-incompatible kidney transplantation

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Rob HigginsDavid Briggs

Abstract

Double filtration plasmapheresis (DFPP) was used in preference to plasma exchange in our program of antibody-incompatible transplantation, to treat higher volumes of plasma. Forty-two patients had 259 sessions of DFPP, 201 pre-transplant and 58 post-transplant. At the first treatment session, the mean plasma volume treated was 3.81 L (range 3-6 L), 55.5 mL/kg (range 36.2-83.6 mL/kg). Serum IgG fell by mean 59.4% (SD 10.2%), and IgM by 69.3% (SD 16.1%). Nine patients did not require increases in plasma volumes treated, and six did not tolerate higher plasma volumes. In the remaining patients, the mean maximum plasma volume treated pre-transplant was 6.67 L (range 4-15 L), 96.1 mL/kg (range 60.2-208.9 mL/kg). The complement dependent cytotoxic crossmatch was positive in 14 cases pre-treatment, and remained positive in six (42.8%) cases. The flow cytometric crossmatch was positive in 29 cases pre-treatment, and in 21 (72.4%) after DFPP. Post-transplant, DFPP was ineffective at reducing donor specific antibody levels during periods of rapid donor specific antibody synthesis. Post-transplant, the one year graft survival rate was 94%, although there was a high rate of early rejection. In summary, DFPP enabled the treatment of plasma ...Continue Reading

References

Jan 29, 1977·Lancet·C J CardellaG A deVeber
Nov 6, 1998·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M MineshimaT Agishi
Jul 26, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·A Sueoka
Apr 12, 2002·Journal of Clinical Apheresis·Jiann-Horng YehHou-Chang Chiu
Jul 23, 2003·Journal of Clinical Apheresis·Su-Mei LinHou-Chang Chiu
Jul 28, 2004·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shigeru OtsuboHiroshi Toma
Jul 29, 2004·Transplantation·Robert A MontgomeryUNKNOWN Antibody Working Group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization
Jan 26, 2006·Artificial Organs·Jiann-Horng YehChyi-Huey Bai
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M OlaussonS Friman
May 15, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Norio HanafusaToshiro Fujita
Jan 25, 2008·Transplantation·Kazunari Tanabe
Jul 19, 2008·The New England Journal of Medicine·Ashley A VoStanley C Jordan
Nov 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rob HigginsDavid Briggs

❮ Previous
Next ❯

Citations

Aug 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lindsay MuscroftRob Higgins
Aug 22, 2012·QJM : Monthly Journal of the Association of Physicians·A SharifE Kraus
Jan 1, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Farsad EskandaryGeorg A Böhmig
May 20, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giles Walters
Oct 21, 2015·Kidney Research and Clinical Practice·Tai Yeon Koo, Jaeseok Yang
Jan 18, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Devan SinhaRob M Higgins
Dec 17, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rob M HigginsDan A Mitchell
Dec 17, 2011·Journal of Transplantation·Milljae Shin, Sung-Joo Kim
May 18, 2016·Mathematical Biosciences·Yan ZhangNatasha Khovanova
Jul 14, 2012·Current Opinion in Organ Transplantation·Thomas Fehr, Georg Stussi
Sep 6, 2017·Clinical Transplantation·James C H BarnesChristopher H E Imray
Jul 16, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kajohnsak NoppakunNikhom Khamlueang
Apr 4, 2021·Journal of Clinical Medicine·Johan NobleThomas Jouve
Oct 6, 2019·Néphrologie & thérapeutique·Jocelyne Maurizi-BalzanLionel Rostaing
Jun 29, 2021·Frontiers in Immunology·Ashley Y ChoiJean Kwun
Aug 28, 2021·Journal of Clinical Medicine·Danae OlasoJean Kwun
Dec 3, 2010·Current Opinion in Rheumatology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Devan SinhaRob Higgins
Clinical Journal of the American Society of Nephrology : CJASN
James O BurtonChristopher W McIntyre
Clinical Journal of the American Society of Nephrology : CJASN
James O BurtonChristopher W McIntyre
© 2021 Meta ULC. All rights reserved