Abstract
Severe hypertriglyceridemia (HTG) leads to major complications such as acute pancreatitis. Lipoprotein apheresis has been proposed as a therapeutic tool for decreasing triglyceride levels, although experience is limited. To describe our experience with double filtration plasmapheresis (DFPP) in patients with severe HTG and pancreatitis in the plasmapheresis unit of a tertiary hospital in Spain. We recruited 4 patients with severe HTG (triglycerides [TGs] >1000 mg/dL) and acute pancreatitis. All the patients underwent DFPP as part of their treatment. Epidemiologic and laboratory data were collected before and after each plasmapheresis session. The average TG level before plasmapheresis was 3136 mg/dL (35.44 mmol/L; range, 1306-6693 mg/dL, 14.76-75.63 mmol/L), and the average Acute Physiology And Chronic Health Evaluation (APACHE) II level before the first session was 6 (range, 3-8). All patients made a full recovery, with a significant improvement in TG levels after plasmapheresis. The mean number of sessions was 2.1 (range, 1-3), and mean TG level after plasmapheresis was 428 mg/dL (4.84 mmol/L; range, 169-515 mg/dL; 1.91-5.82 mmol/L). After the first session, the mean decrease in TG levels was 69.16% (2169 mg/dL, range, 945-59...Continue Reading
References
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M H Mokrzycki, A A Kaplan
May 4, 2006·Digestive Diseases and Sciences·Hakan AlagözlüSelahattin Unal
Aug 31, 2006·Digestion·A V KyriakidisS Lambropoulos
Mar 25, 2009·Archives of Internal Medicine·Warren G Thompson, Gerald T Gau
Feb 5, 2010·Atherosclerosis. Supplements·Nils Ewald, Hans-Ulrich Kloer
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Feb 20, 2013·Journal of Clinical Apheresis·Andre A Kaplan
Feb 20, 2013·Journal of Clinical Apheresis·Amber P SanchezDavid M Ward
Apr 27, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Juan Pablo CórdobaAlvaro Ruiz
Jul 28, 2013·Clinical and Experimental Nephrology·Takeshi NakanishiYukiko Hasuike
Aug 19, 2014·Lancet·Børge G Nordestgaard, Anette Varbo
Oct 2, 2014·European Journal of Internal Medicine·Pedro ValdivielsoNils Ewald
Mar 25, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Benjamin ClickDhiraj Yadav
Citations
Dec 1, 2017·Expert Review of Cardiovascular Therapy·Bogusław OkopieńAleksandra Bołdys
Nov 17, 2017·World Journal of Gastroenterology : WJG·Mohannad Abou SalehGregory S Cooper
Mar 20, 2020·ANZ Journal of Surgery·Renee TaboneTerence C Chua
May 17, 2017·Therapeutic Advances in Endocrinology and Metabolism·Kiran JoglekarAmik Sodhi
May 12, 2019·Journal of Internal Medicine·Amanda J BerberichRobert A Hegele
Oct 14, 2020·BMJ : British Medical Journal·Vinaya Simha
Oct 25, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Gulay Simsek Bagirİlknur Kozanoglu
May 1, 2021·Biochemia Medica·Jan Van ElslandePieter Vermeersch