Double GnRH-antagonist dose before HCG administration may prevent OHSS in oocyte-donor cycles: a pilot study

Reproductive Biomedicine Online
Y PrapasNikos Prapas

Abstract

This pilot study evaluated the possibility of preventing early ovarian hyperstimulation syndrome (OHSS) by increasing the daily dose of gonadotrophin-releasing hormone (GnRH) antagonist administration (to twice a day) in oocyte-donor cycles stimulated with the antagonist protocol. The study included 72 oocyte donors who underwent ovarian stimulation using the GnRH antagonist protocol and might have had their cycle cancelled because of ovarian hyper-response. All women were donors presenting a rapid rise of oestradiol > or = 3000 pg/ml early in the stimulation period with more than 15 follicles of < or = 15 mm in diameter. By decreasing the rFSH dose to 75 IU a day with an additional daily dose of GnRH antagonist (0.25 mg twice a day), the oestradiol concentrations were lowered or reached a plateau before human chorionic gonadotrophin was given. A marked decrease in oestradiol concentrations and ovarian volume was observed on the day of oocyte retrieval and 3 days post retrieval. None of the donors needed coasting, were cancelled or developed OHSS. In over-responding oocyte donors, by increasing the usual GnRH-antagonist dose to twice a day during ovarian stimulation, the oestradiol rise can be blocked while a minimal follicular...Continue Reading

References

Jun 25, 2002·Human Reproduction Update·F OlivennesR Frydman
Dec 25, 2002·Human Reproduction Update·Annick Delvigne, Serge Rozenberg
Mar 8, 2005·Fertility and Sterility·Daniel B ShapiroZsolt Peter Nagy
Feb 28, 2006·Fertility and Sterility·Juan A García-VelascoAntonio Pellicer
Oct 24, 2006·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Jan 2, 2008·Fertility and Sterility·Rachel Michaelson-CohenTalia Eldar-Geva
Apr 4, 2008·Human Reproduction Update·Sérgio Reis SoaresAntonio Pellicer
Jun 17, 2008·Fertility and Sterility·Eleuterio R HernándezElisabetta Ricciarelli
Aug 12, 2008·Fertility and Sterility·Juan GilesAntonio Pellicer

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Citations

Jul 5, 2013·International Journal of Endocrinology and Metabolism·Pilar AlamaJuan Giles
Jun 16, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marzieh Agha HosseiniFatemeh Bahmaee
Sep 25, 2012·Reproductive Biomedicine Online·Yannis PrapasNikos Prapas

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